A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

Javier Margareto; Miriam Aguado; Juan A. Osés-Prieto; Isabel Rivero; Antonio Monge; Ignacio Aldana; Amelia Marti; J. Alfredo Martínez

doi:10.1016/S0024-3205(00)00916-4

A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

Javier Margareto
, Miriam Aguado
, Juan A. Osés-Prieto
, Isabel Rivero
, Antonio Monge
, Ignacio Aldana
, Amelia Marti
, J. Alfredo Martínez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet. (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Life Sciences
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/S0024-3205(00)00916-4
Publication status	Published - 24 Nov 2000
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
High-fat diets
Lipolysis
NPY-antagonist
Obesity
White Adipose Tissue

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10.1016/S0024-3205(00)00916-4

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title = "A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model",

abstract = "Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet. (C) 2000 Elsevier Science Inc.",

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T1 - A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

AU - Margareto, Javier

AU - Aguado, Miriam

AU - Osés-Prieto, Juan A.

AU - Rivero, Isabel

AU - Monge, Antonio

AU - Aldana, Ignacio

AU - Marti, Amelia

AU - Martínez, J. Alfredo

PY - 2000/11/24

Y1 - 2000/11/24

N2 - Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet. (C) 2000 Elsevier Science Inc.

AB - Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet. (C) 2000 Elsevier Science Inc.

KW - Apoptosis

KW - High-fat diets

KW - Lipolysis

KW - NPY-antagonist

KW - Obesity

KW - White Adipose Tissue

UR - https://www.scopus.com/pages/publications/0034711448

U2 - 10.1016/S0024-3205(00)00916-4

DO - 10.1016/S0024-3205(00)00916-4

M3 - Article

C2 - 11132250

AN - SCOPUS:0034711448

SN - 0024-3205

VL - 68

SP - 99

EP - 107

JO - Life Sciences

JF - Life Sciences

IS - 1

ER -

A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

Abstract

UN SDGs

Keywords

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