Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs

Nerea Argarate; Beatriz Olalde; Garbiñe Atorrasagasti; Jesus Valero; Sandra Carolina Cifuentes; Rosario Benavente; Marcela Lieblich; José Luis González-Carrasco

doi:10.1016/j.matlet.2014.06.070

Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs

Nerea Argarate, Beatriz Olalde, Garbiñe Atorrasagasti, Jesus Valero, Sandra Carolina Cifuentes, Rosario Benavente, Marcela Lieblich, José Luis González-Carrasco

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.

Original language	English
Pages (from-to)	193-195
Number of pages	3
Journal	Materials Letters
Volume	132
DOIs	https://doi.org/10.1016/j.matlet.2014.06.070
Publication status	Published - 1 Oct 2014

Keywords

Biodegradable polymers
Controlled release
Dip coating
Orthopaedic implants

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abstract = "A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.",

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T1 - Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs

AU - Argarate, Nerea

AU - Olalde, Beatriz

AU - Atorrasagasti, Garbiñe

AU - Valero, Jesus

AU - Carolina Cifuentes, Sandra

AU - Benavente, Rosario

AU - Lieblich, Marcela

AU - Luis González-Carrasco, José

PY - 2014/10/1

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N2 - A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.

AB - A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.

KW - Biodegradable polymers

KW - Controlled release

KW - Dip coating

KW - Orthopaedic implants

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JO - Materials Letters

JF - Materials Letters

ER -

Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs

Abstract

Keywords

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