Celiac disease biodetection using lossy-mode resonances generated in tapered single-mode optical fibers

  • A. B. Socorro*
  • , J. M. Corres
  • , I. Del Villar
  • , I. R. Matias
  • , F. J. Arregui
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

This work presents the development and test of an anti-gliadin antibodies biosensor based on lossy mode resonances (LMRs) to detect celiac disease. Several polyelectrolites were used to perform layer-by-layer assembly processes in order to generate the LMR and to fabricate a gliadin-embedded thin-film. The LMR shifted 20 nm when immersed in a 5 ppm anti-gliadin antibodies-PBS solution, what makes this bioprobe suitable for detecting celiac disease. This is the first time, to our knowledge, that LMRs are used to detect celiac disease and these results suppose promising prospects on the use of such phenomena as biological detectors.

Original languageEnglish
Title of host publication23rd International Conference on Optical Fibre Sensors
PublisherSPIE
ISBN (Print)9781628411751
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event23rd International Conference on Optical Fibre Sensors - Santander, Spain
Duration: 2 Jun 20146 Jun 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9157
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference23rd International Conference on Optical Fibre Sensors
Country/TerritorySpain
CitySantander
Period2/06/146/06/14

Keywords

  • Biosensors
  • Celiac disease
  • Lossy mode resonances
  • Tapered single-mode optical fiber
  • Thin-film

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