Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

Iñaki Ortego-Isasa; Juan Francisco Ortega-Morán; Héctor Lozano; Thomas Stieglitz; Francisco M. Sánchez-Margallo; Jesús Usón-Gargallo; J. Blas Pagador; Ander Ramos-Murguialday

doi:10.3390/biomedicines12030481

Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

Iñaki Ortego-Isasa^*, Juan Francisco Ortega-Morán, Héctor Lozano, Thomas Stieglitz, Francisco M. Sánchez-Margallo, Jesús Usón-Gargallo, J. Blas Pagador^*, Ander Ramos-Murguialday

^*Corresponding author for this work

Neuroengineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

Original language	English
Article number	481
Journal	Biomedicines
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/biomedicines12030481
Publication status	Published - Mar 2024

Keywords

bioelectronics
colonic electric stimulation (CES)
constipation
neural implant

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10.3390/biomedicines12030481

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title = "Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review",

abstract = "Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.",

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AU - Ortego-Isasa, Iñaki

AU - Ortega-Morán, Juan Francisco

AU - Lozano, Héctor

AU - Stieglitz, Thomas

AU - Sánchez-Margallo, Francisco M.

AU - Usón-Gargallo, Jesús

AU - Pagador, J. Blas

AU - Ramos-Murguialday, Ander

PY - 2024/3

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N2 - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

AB - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

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Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

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