@inbook{b6685262251145b98495d64426ea5a85,
title = "Continuous monitoring of molecular biomarkers in microfluidic devices",
abstract = "The ability to monitor molecular targets is crucial in fields ranging from healthcare to industrial processing to environmental protection. Devices employing biomolecules to achieve this goal are called biosensors. Over the last half century researchers have developed dozens of different biosensor approaches. In this chapter we analyze recent advances in the biosensing field aiming at adapting these to the problem of continuous molecular monitoring in complex sample streams, and how the merging of these sensors with lab-on-a-chip technologies would be beneficial to both. To do so we discuss (1) the components that comprise a biosensor, (2) the challenges associated with continuous molecular monitoring in complex sample streams, (3) how different sensing strategies deal with (or fail to deal with) these challenges, and (4) the implementation of these technologies into lab-on-a-chip architectures.",
keywords = "Analytical devices, Biosensors, Continuous sensing, Diagnostics, Real-time sensing",
author = "Andrea Idili and Helena Mont{\'o}n and Mariana Medina-S{\'a}nchez and Bergoi Ibarlucea and Gianaurelio Cuniberti and Schmidt, \{Oliver G.\} and Plaxco, \{Kevin W.\} and Claudio Parolo",
note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.pmbts.2021.07.027",
language = "English",
isbn = "9780323853033",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
number = "1",
pages = "295--333",
editor = "Alok Pandya and Vijai Singh",
booktitle = "Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B",
edition = "1",
}