TY - JOUR
T1 - Effect of β-cyclodextrin on the transfer of N1-substituted sulfonamides from water to chloroform
AU - De Namor, Angela F.Danil
AU - Tanaka, David Alfredo Pacheco
AU - Regueira, Lisardo Nuñez
AU - Orellana, Isabel Gomez
PY - 1992
Y1 - 1992
N2 - Solubility data for several N1-substituted sulfonamides in water and in chloroform at 298.15 K and derived Gibbs energies of transfer of these drugs from water to chloroform are reported. Stability constants, derived Gibbs energies, enthalpies and entropies of complexation of these drugs with β-cyclodextrin as obtained by titration microcalorimetry in water are given. Gibbs energy data are used to evaluate the effect of β-cyclodextrin on the transfer of the drug from water to chloroform. It is concluded that is the process of transfer of the drug in this solvent system is thermodynamically more favoured in the absence of cyclodextrin.
AB - Solubility data for several N1-substituted sulfonamides in water and in chloroform at 298.15 K and derived Gibbs energies of transfer of these drugs from water to chloroform are reported. Stability constants, derived Gibbs energies, enthalpies and entropies of complexation of these drugs with β-cyclodextrin as obtained by titration microcalorimetry in water are given. Gibbs energy data are used to evaluate the effect of β-cyclodextrin on the transfer of the drug from water to chloroform. It is concluded that is the process of transfer of the drug in this solvent system is thermodynamically more favoured in the absence of cyclodextrin.
UR - https://www.scopus.com/pages/publications/0011322677
U2 - 10.1039/FT9928801665
DO - 10.1039/FT9928801665
M3 - Article
AN - SCOPUS:0011322677
SN - 0956-5000
VL - 88
SP - 1665
EP - 1668
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
IS - 12
ER -