Effectiveness of subunit influenza vaccination in the 2014-2015 season and residual effect of split vaccination in previous seasons

Network for Influenza Surveillance in Hospitals of Navarra; Primary Health Care Sentinel Network

doi:10.1016/j.vaccine.2016.01.054

Effectiveness of subunit influenza vaccination in the 2014-2015 season and residual effect of split vaccination in previous seasons

Network for Influenza Surveillance in Hospitals of Navarra
, Primary Health Care Sentinel Network

Circular Traceability

Navarre Institute for Health Research
Instituto de Salud Carlos III
Hospital Reina Sofia
Hospital García Orcoyen
Servicio Navarro de Salud
Instituto deSalud Pública de Navarra

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: In Navarra, Spain, subunit vaccine was first used in the 2014-2015 season, whereas trivalent split-virion influenza vaccines had been used in previous seasons. We estimate the effectiveness of the subunit vaccine in the current season and split vaccine in the two previous seasons against laboratory-confirmed influenza in the 2014-2015 season. Methods: Patients with influenza-like illness hospitalized or attended by sentinel general practitioners were swabbed for influenza testing. The previous and current vaccine status of laboratory-confirmed cases was compared to test-negative controls. Results: Among 1213 patients tested, 619 (51%) were confirmed for influenza virus: 52% influenza A(H3N2), 46% influenza B, and 2% A(H1N1)pdm09. The overall effectiveness for subunit vaccination in the current season was 19% (95% confidence interval [CI]: -13 to 42), 2% (95%CI: -47 to 35) against influenza A(H3N2) and 32% (95%CI: -4 to 56) against influenza B. The effectiveness against any influenza was 67% (95%CI: 17-87) for 2012-2013 and 2013-2014 vaccination only, 42% (95%CI: -31 to 74) for 2014-2015 vaccination only, and 38% (95%CI: 8-58) for vaccination in the 2012-2013, 2013-2014 and 2014-2015 seasons. The same estimates against influenza A(H3N2) were 47% (95%CI: -60 to 82), -54% (95%CI: -274 to 37) and 28% (95%CI: -17 to 56), and against influenza B were 82% (95%CI: 19-96), 93% (95%CI: 45-99) and 43% (95%CI: 5-66), respectively. Conclusion: These results suggest a considerable residual protection of split vaccination in previous seasons, low overall effectiveness of current season subunit vaccination, and possible interference between current subunit and previous split vaccines.

Original language	English
Pages (from-to)	1350-1357
Number of pages	8
Journal	Vaccine
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.vaccine.2016.01.054
Publication status	Published - 8 Mar 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Influenza
Influenza vaccine
Split-virion vaccine
Subunit vaccine
Vaccine effectiveness

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10.1016/j.vaccine.2016.01.054

Effectiveness of subunit influenzaFinal published version, 917 KBLicence: Unspecified

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@article{663a14e30a014af99a8fc77717d90d35,

title = "Effectiveness of subunit influenza vaccination in the 2014-2015 season and residual effect of split vaccination in previous seasons",

abstract = "Background: In Navarra, Spain, subunit vaccine was first used in the 2014-2015 season, whereas trivalent split-virion influenza vaccines had been used in previous seasons. We estimate the effectiveness of the subunit vaccine in the current season and split vaccine in the two previous seasons against laboratory-confirmed influenza in the 2014-2015 season. Methods: Patients with influenza-like illness hospitalized or attended by sentinel general practitioners were swabbed for influenza testing. The previous and current vaccine status of laboratory-confirmed cases was compared to test-negative controls. Results: Among 1213 patients tested, 619 (51\%) were confirmed for influenza virus: 52\% influenza A(H3N2), 46\% influenza B, and 2\% A(H1N1)pdm09. The overall effectiveness for subunit vaccination in the current season was 19\% (95\% confidence interval [CI]: -13 to 42), 2\% (95\%CI: -47 to 35) against influenza A(H3N2) and 32\% (95\%CI: -4 to 56) against influenza B. The effectiveness against any influenza was 67\% (95\%CI: 17-87) for 2012-2013 and 2013-2014 vaccination only, 42\% (95\%CI: -31 to 74) for 2014-2015 vaccination only, and 38\% (95\%CI: 8-58) for vaccination in the 2012-2013, 2013-2014 and 2014-2015 seasons. The same estimates against influenza A(H3N2) were 47\% (95\%CI: -60 to 82), -54\% (95\%CI: -274 to 37) and 28\% (95\%CI: -17 to 56), and against influenza B were 82\% (95\%CI: 19-96), 93\% (95\%CI: 45-99) and 43\% (95\%CI: 5-66), respectively. Conclusion: These results suggest a considerable residual protection of split vaccination in previous seasons, low overall effectiveness of current season subunit vaccination, and possible interference between current subunit and previous split vaccines.",

keywords = "Influenza, Influenza vaccine, Split-virion vaccine, Subunit vaccine, Vaccine effectiveness",

author = "\{Network for Influenza Surveillance in Hospitals of Navarra\} and \{Primary Health Care Sentinel Network\} and Jes{\'u}s Castilla and Ana Navascu{\'e}s and Mirian Fern{\'a}ndez-Alonso and Gabriel Reina and Francisco Pozo and Itziar Casado and Marcela Guevara and Iv{\'a}n Mart{\'i}nez-Baz and Aurelio Barricarte and Carmen Ezpeleta and I. Abad and P. Aldaz and E. {\'A}lvarez and N. {\'A}lvarez and Arana, \{J. J.\} and I. Arceiz and E. Arina and I. Arribas and Artajo, \{M. D.\} and B. Azagra and Bartolome, \{F. C.\} and C. Bolea and A. Brugos and B. Cano and Castresana, \{M. V.\} and Cenoz, \{J. C.\} and F. C{\'i}a and B. Compains and F. Cort{\'e}s and B. Chur{\'i}o and Cuevas, \{P. C.\} and \{Da Costa\}, \{E. M.\} and \{D{\'i}ez Espino\}, J. and M. Doiz and Escribano, \{F. J.\} and Esparza, \{M. J.\} and V. Etayo and \{Fern{\'a}ndez Alfaro\}, C. and B. Flamarique and J. Gamboa and Gar-c{\'e}s, \{M. L.\} and \{Garc{\'i}a Blanco\}, L. and German, \{A. B.\} and A. Giner and N. Go{\~n}i and Guillorme, \{M. J.\} and Guiu, \{J. O.\} and Gurbindo, \{J. C.\} and Guruchaga, \{M. J.\} and Heras, \{J. A.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = mar,

day = "8",

doi = "10.1016/j.vaccine.2016.01.054",

language = "English",

volume = "34",

pages = "1350--1357",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "11",

}

TY - JOUR

T1 - Effectiveness of subunit influenza vaccination in the 2014-2015 season and residual effect of split vaccination in previous seasons

AU - Network for Influenza Surveillance in Hospitals of Navarra

AU - Primary Health Care Sentinel Network

AU - Castilla, Jesús

AU - Navascués, Ana

AU - Fernández-Alonso, Mirian

AU - Reina, Gabriel

AU - Pozo, Francisco

AU - Casado, Itziar

AU - Guevara, Marcela

AU - Martínez-Baz, Iván

AU - Barricarte, Aurelio

AU - Ezpeleta, Carmen

AU - Abad, I.

AU - Aldaz, P.

AU - Álvarez, E.

AU - Álvarez, N.

AU - Arana, J. J.

AU - Arceiz, I.

AU - Arina, E.

AU - Arribas, I.

AU - Artajo, M. D.

AU - Azagra, B.

AU - Bartolome, F. C.

AU - Bolea, C.

AU - Brugos, A.

AU - Cano, B.

AU - Castresana, M. V.

AU - Cenoz, J. C.

AU - Cía, F.

AU - Compains, B.

AU - Cortés, F.

AU - Churío, B.

AU - Cuevas, P. C.

AU - Da Costa, E. M.

AU - Díez Espino, J.

AU - Doiz, M.

AU - Escribano, F. J.

AU - Esparza, M. J.

AU - Etayo, V.

AU - Fernández Alfaro, C.

AU - Flamarique, B.

AU - Gamboa, J.

AU - Gar-cés, M. L.

AU - García Blanco, L.

AU - German, A. B.

AU - Giner, A.

AU - Goñi, N.

AU - Guillorme, M. J.

AU - Guiu, J. O.

AU - Gurbindo, J. C.

AU - Guruchaga, M. J.

AU - Heras, J. A.

PY - 2016/3/8

Y1 - 2016/3/8

N2 - Background: In Navarra, Spain, subunit vaccine was first used in the 2014-2015 season, whereas trivalent split-virion influenza vaccines had been used in previous seasons. We estimate the effectiveness of the subunit vaccine in the current season and split vaccine in the two previous seasons against laboratory-confirmed influenza in the 2014-2015 season. Methods: Patients with influenza-like illness hospitalized or attended by sentinel general practitioners were swabbed for influenza testing. The previous and current vaccine status of laboratory-confirmed cases was compared to test-negative controls. Results: Among 1213 patients tested, 619 (51%) were confirmed for influenza virus: 52% influenza A(H3N2), 46% influenza B, and 2% A(H1N1)pdm09. The overall effectiveness for subunit vaccination in the current season was 19% (95% confidence interval [CI]: -13 to 42), 2% (95%CI: -47 to 35) against influenza A(H3N2) and 32% (95%CI: -4 to 56) against influenza B. The effectiveness against any influenza was 67% (95%CI: 17-87) for 2012-2013 and 2013-2014 vaccination only, 42% (95%CI: -31 to 74) for 2014-2015 vaccination only, and 38% (95%CI: 8-58) for vaccination in the 2012-2013, 2013-2014 and 2014-2015 seasons. The same estimates against influenza A(H3N2) were 47% (95%CI: -60 to 82), -54% (95%CI: -274 to 37) and 28% (95%CI: -17 to 56), and against influenza B were 82% (95%CI: 19-96), 93% (95%CI: 45-99) and 43% (95%CI: 5-66), respectively. Conclusion: These results suggest a considerable residual protection of split vaccination in previous seasons, low overall effectiveness of current season subunit vaccination, and possible interference between current subunit and previous split vaccines.

AB - Background: In Navarra, Spain, subunit vaccine was first used in the 2014-2015 season, whereas trivalent split-virion influenza vaccines had been used in previous seasons. We estimate the effectiveness of the subunit vaccine in the current season and split vaccine in the two previous seasons against laboratory-confirmed influenza in the 2014-2015 season. Methods: Patients with influenza-like illness hospitalized or attended by sentinel general practitioners were swabbed for influenza testing. The previous and current vaccine status of laboratory-confirmed cases was compared to test-negative controls. Results: Among 1213 patients tested, 619 (51%) were confirmed for influenza virus: 52% influenza A(H3N2), 46% influenza B, and 2% A(H1N1)pdm09. The overall effectiveness for subunit vaccination in the current season was 19% (95% confidence interval [CI]: -13 to 42), 2% (95%CI: -47 to 35) against influenza A(H3N2) and 32% (95%CI: -4 to 56) against influenza B. The effectiveness against any influenza was 67% (95%CI: 17-87) for 2012-2013 and 2013-2014 vaccination only, 42% (95%CI: -31 to 74) for 2014-2015 vaccination only, and 38% (95%CI: 8-58) for vaccination in the 2012-2013, 2013-2014 and 2014-2015 seasons. The same estimates against influenza A(H3N2) were 47% (95%CI: -60 to 82), -54% (95%CI: -274 to 37) and 28% (95%CI: -17 to 56), and against influenza B were 82% (95%CI: 19-96), 93% (95%CI: 45-99) and 43% (95%CI: 5-66), respectively. Conclusion: These results suggest a considerable residual protection of split vaccination in previous seasons, low overall effectiveness of current season subunit vaccination, and possible interference between current subunit and previous split vaccines.

KW - Influenza

KW - Influenza vaccine

KW - Split-virion vaccine

KW - Subunit vaccine

KW - Vaccine effectiveness

UR - https://www.scopus.com/pages/publications/84959087903

U2 - 10.1016/j.vaccine.2016.01.054

DO - 10.1016/j.vaccine.2016.01.054

M3 - Article

C2 - 26854911

AN - SCOPUS:84959087903

SN - 0264-410X

VL - 34

SP - 1350

EP - 1357

JO - Vaccine

JF - Vaccine

IS - 11

ER -

Effectiveness of subunit influenza vaccination in the 2014-2015 season and residual effect of split vaccination in previous seasons

Abstract

UN SDGs

Keywords

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