Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal

M. Luisa Vargas; M. Luisa Gonzalvez; J. Antonio Martinez; Lourdes Arias; Arturo J. Bruger; M. Victoria Milanés

doi:10.1159/000138908

Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal

M. Luisa Vargas^*
, M. Luisa Gonzalvez
, J. Antonio Martinez
, Lourdes Arias
, Arturo J. Bruger
, M. Victoria Milanés

^*Corresponding author for this work

Department of Pharmacy, Clinic Hospital

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5 and 1 mg⁄kg s.c.) significantly increased plasma β-endorphin-like immunoreactivity (β-END-LI) and cortisol levels. This effect was significantly reduced in morphine-tolerant animals. Naloxone treatment induced an increase of plasma β-END-Ll and cortisol levels in morphine-tolerant animals. The increase in cortisol level after withdrawal was significantly reduced by clonidine. These results are consistent with an interaction between α₂-adrenoceptors and opioid systems in the control of pituitary-adrenocortical axis during morphine tolerance and withdrawal.

Original language	English
Pages (from-to)	158-164
Number of pages	7
Journal	Pharmacology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1159/000138908
Publication status	Published - 1992
Externally published	Yes

Keywords

Clonidine
Morphine tolerance
Naloxone-induced
Pituitary-adrenocortical axis
Withdrawal

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10.1159/000138908

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title = "Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal",

abstract = "The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5 and 1 mg⁄kg s.c.) significantly increased plasma β-endorphin-like immunoreactivity (β-END-LI) and cortisol levels. This effect was significantly reduced in morphine-tolerant animals. Naloxone treatment induced an increase of plasma β-END-Ll and cortisol levels in morphine-tolerant animals. The increase in cortisol level after withdrawal was significantly reduced by clonidine. These results are consistent with an interaction between α2-adrenoceptors and opioid systems in the control of pituitary-adrenocortical axis during morphine tolerance and withdrawal.",

keywords = "Clonidine, Morphine tolerance, Naloxone-induced, Pituitary-adrenocortical axis, Withdrawal",

author = "Vargas, \{M. Luisa\} and Gonzalvez, \{M. Luisa\} and Martinez, \{J. Antonio\} and Lourdes Arias and Bruger, \{Arturo J.\} and Milan{\'e}s, \{M. Victoria\}",

year = "1992",

doi = "10.1159/000138908",

language = "English",

volume = "44",

pages = "158--164",

journal = "Pharmacology",

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TY - JOUR

T1 - Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal

AU - Vargas, M. Luisa

AU - Gonzalvez, M. Luisa

AU - Martinez, J. Antonio

AU - Arias, Lourdes

AU - Bruger, Arturo J.

AU - Milanés, M. Victoria

PY - 1992

Y1 - 1992

N2 - The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5 and 1 mg⁄kg s.c.) significantly increased plasma β-endorphin-like immunoreactivity (β-END-LI) and cortisol levels. This effect was significantly reduced in morphine-tolerant animals. Naloxone treatment induced an increase of plasma β-END-Ll and cortisol levels in morphine-tolerant animals. The increase in cortisol level after withdrawal was significantly reduced by clonidine. These results are consistent with an interaction between α2-adrenoceptors and opioid systems in the control of pituitary-adrenocortical axis during morphine tolerance and withdrawal.

AB - The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5 and 1 mg⁄kg s.c.) significantly increased plasma β-endorphin-like immunoreactivity (β-END-LI) and cortisol levels. This effect was significantly reduced in morphine-tolerant animals. Naloxone treatment induced an increase of plasma β-END-Ll and cortisol levels in morphine-tolerant animals. The increase in cortisol level after withdrawal was significantly reduced by clonidine. These results are consistent with an interaction between α2-adrenoceptors and opioid systems in the control of pituitary-adrenocortical axis during morphine tolerance and withdrawal.

KW - Clonidine

KW - Morphine tolerance

KW - Naloxone-induced

KW - Pituitary-adrenocortical axis

KW - Withdrawal

UR - https://www.scopus.com/pages/publications/0026572132

U2 - 10.1159/000138908

DO - 10.1159/000138908

M3 - Article

C2 - 1579597

AN - SCOPUS:0026572132

SN - 0031-7012

VL - 44

SP - 158

EP - 164

JO - Pharmacology

JF - Pharmacology

IS - 3

ER -

Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal

Abstract

Keywords

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