Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum

M. L. Vargas; J. A. Martinez; M. V. Milanes

doi:10.1016/0306-3623(87)90012-7

Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum

M. L. Vargas^*
, J. A. Martinez
, M. V. Milanes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

1. 1. Acute administration of droperidol 2 or 5 mg kg^-1 induced an increase in the inhibitory response obtained by stimulation at 10 Hz of the myenteric plexus longitudinal muscle preparation of the guinea-pig ileum. 2. 2. The increase in the response induced by droperidol was markedly reduced by naloxone which suggests that it is mediated by endogenous opioid release. 3. 3. Cycloheximide treatment significantly reduced the increase of the inhibitory response induced by droperidol, indicating that the biosynthesis and the release of endogenous opioid are increased by droperidol.

Original language	English
Pages (from-to)	283-286
Number of pages	4
Journal	Vascular Pharmacology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/0306-3623(87)90012-7
Publication status	Published - 1987
Externally published	Yes

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title = "Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum",

abstract = "1. 1. Acute administration of droperidol 2 or 5 mg kg-1 induced an increase in the inhibitory response obtained by stimulation at 10 Hz of the myenteric plexus longitudinal muscle preparation of the guinea-pig ileum. 2. 2. The increase in the response induced by droperidol was markedly reduced by naloxone which suggests that it is mediated by endogenous opioid release. 3. 3. Cycloheximide treatment significantly reduced the increase of the inhibitory response induced by droperidol, indicating that the biosynthesis and the release of endogenous opioid are increased by droperidol.",

author = "Vargas, \{M. L.\} and Martinez, \{J. A.\} and Milanes, \{M. V.\}",

year = "1987",

doi = "10.1016/0306-3623(87)90012-7",

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journal = "Vascular Pharmacology",

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T1 - Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum

AU - Vargas, M. L.

AU - Martinez, J. A.

AU - Milanes, M. V.

PY - 1987

Y1 - 1987

N2 - 1. 1. Acute administration of droperidol 2 or 5 mg kg-1 induced an increase in the inhibitory response obtained by stimulation at 10 Hz of the myenteric plexus longitudinal muscle preparation of the guinea-pig ileum. 2. 2. The increase in the response induced by droperidol was markedly reduced by naloxone which suggests that it is mediated by endogenous opioid release. 3. 3. Cycloheximide treatment significantly reduced the increase of the inhibitory response induced by droperidol, indicating that the biosynthesis and the release of endogenous opioid are increased by droperidol.

AB - 1. 1. Acute administration of droperidol 2 or 5 mg kg-1 induced an increase in the inhibitory response obtained by stimulation at 10 Hz of the myenteric plexus longitudinal muscle preparation of the guinea-pig ileum. 2. 2. The increase in the response induced by droperidol was markedly reduced by naloxone which suggests that it is mediated by endogenous opioid release. 3. 3. Cycloheximide treatment significantly reduced the increase of the inhibitory response induced by droperidol, indicating that the biosynthesis and the release of endogenous opioid are increased by droperidol.

UR - https://www.scopus.com/pages/publications/0023110270

U2 - 10.1016/0306-3623(87)90012-7

DO - 10.1016/0306-3623(87)90012-7

M3 - Article

C2 - 3569853

AN - SCOPUS:0023110270

SN - 0306-3623

VL - 18

SP - 283

EP - 286

JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 3

ER -

Effects of droperidol on the biosynthesis and release of endogenous opioid peptides in guinea-pig ileum

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