Experimental results of antigliadin antibodies detection using long period fiber grating

  • J. M. Corres
  • , I. R. Matias
  • , J. Goicoechea
  • , F. J. Arregui
  • , D. Viegas*
  • , F. M. Araújo
  • , J. L. Santos
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Citations (Scopus)

Abstract

In this work a new nano-biofilm is proposed for the detection of celiac disease (CD). A long-period fiber grating (LPFG) is used as a transducer and the surface of the fiber is coated with a precursor layer of SiO 2-nanospheres using the electrostatic self-assembly technique (ESA). This layer has been designed in order to create a substrate of high porosity where the gliadins could be deposited. Under the presence of specific antibodies antigliadin antibodies (AGA) the refractive index of the overlay changes giving a detectable shift in the resonance wavelength of the LPFG. Concentrations as low as 5 ppm were detected.

Original languageEnglish
Title of host publication19th International Conference on Optical Fibre Sensors
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event19th International Conference on Optical Fibre Sensors - Perth, WA, Australia
Duration: 15 Apr 200818 Apr 2008

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7004
ISSN (Print)0277-786X

Conference

Conference19th International Conference on Optical Fibre Sensors
Country/TerritoryAustralia
CityPerth, WA
Period15/04/0818/04/08

Keywords

  • Celiac disease biosensor
  • ESA technique
  • Long-period fiber grating
  • SiO- nanospheres

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