Genotoxic activity of halogenated phenylglycine derivatives

Alicia Boto; Juan A. Gallardo; Rosendo Hernández; Francisco Ledo; Ana Muñoz; José R. Murguía; Mauricio Menacho-Márquez; Aurelio Orjales; Carlos J. Saavedra

doi:10.1016/j.bmcl.2006.08.111

Genotoxic activity of halogenated phenylglycine derivatives

Alicia Boto^*
, Juan A. Gallardo
, Rosendo Hernández
, Francisco Ledo
, Ana Muñoz
, José R. Murguía
, Mauricio Menacho-Márquez
, Aurelio Orjales
, Carlos J. Saavedra

^*Corresponding author for this work

CSIC - Instituto de Productos Naturales y Agrobiologia (IPNA)
Faes Farma, S.A.
Hospital Universitario de Canarias

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

Original language	English
Pages (from-to)	6073-6077
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2006.08.111
Publication status	Published - 1 Dec 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amino acids
Cancer
Cytotoxic
Genotoxic
Phenylglycine

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10.1016/j.bmcl.2006.08.111

Cite this

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title = "Genotoxic activity of halogenated phenylglycine derivatives",

abstract = "The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.",

keywords = "Amino acids, Cancer, Cytotoxic, Genotoxic, Phenylglycine",

author = "Alicia Boto and Gallardo, \{Juan A.\} and Rosendo Hern{\'a}ndez and Francisco Ledo and Ana Mu{\~n}oz and Murgu{\'i}a, \{Jos{\'e} R.\} and Mauricio Menacho-M{\'a}rquez and Aurelio Orjales and Saavedra, \{Carlos J.\}",

year = "2006",

month = dec,

day = "1",

doi = "10.1016/j.bmcl.2006.08.111",

language = "English",

volume = "16",

pages = "6073--6077",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "23",

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TY - JOUR

T1 - Genotoxic activity of halogenated phenylglycine derivatives

AU - Boto, Alicia

AU - Gallardo, Juan A.

AU - Hernández, Rosendo

AU - Ledo, Francisco

AU - Muñoz, Ana

AU - Murguía, José R.

AU - Menacho-Márquez, Mauricio

AU - Orjales, Aurelio

AU - Saavedra, Carlos J.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

AB - The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

KW - Amino acids

KW - Cancer

KW - Cytotoxic

KW - Genotoxic

KW - Phenylglycine

UR - https://www.scopus.com/pages/publications/33751035186

U2 - 10.1016/j.bmcl.2006.08.111

DO - 10.1016/j.bmcl.2006.08.111

M3 - Article

C2 - 16990000

AN - SCOPUS:33751035186

SN - 0960-894X

VL - 16

SP - 6073

EP - 6077

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Genotoxic activity of halogenated phenylglycine derivatives

Abstract

UN SDGs

Keywords

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