Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release

I. Echeverria; I. Silva; M. Gurruchaga; I. Goñi

Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release

I. Echeverria^*
, I. Silva
, M. Gurruchaga
, I. Goñi

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The ability of acrylic/starch graft copolymers to release drugs in the physiological medium with a release profile was demonstrated which depends on the acrylic component. The preparation of the grafted copolymer was carried out using buthyl methacrylate (BMA) (Merck), hydroxypropyl starch (HS), potato starch (S) (AVEBE) and ceric ammonium nitrate (CAN) (Fluka) as initiator. Grafting was allowed to proceed for 4h. under a constant light source using 149.62 ml of BMA. The release kinetics of the drug was subjected to in vitro dissolution test. The results show that the presence of the branches of PBMA decreases the hydrophilicity.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	1160
Number of pages	1
Publication status	Published - 2004
Externally published	Yes
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Conference

Conference	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

@inproceedings{1ce8283e0df8418eb111cfa78de6c1be,

title = "Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release",

abstract = "The ability of acrylic/starch graft copolymers to release drugs in the physiological medium with a release profile was demonstrated which depends on the acrylic component. The preparation of the grafted copolymer was carried out using buthyl methacrylate (BMA) (Merck), hydroxypropyl starch (HS), potato starch (S) (AVEBE) and ceric ammonium nitrate (CAN) (Fluka) as initiator. Grafting was allowed to proceed for 4h. under a constant light source using 149.62 ml of BMA. The release kinetics of the drug was subjected to in vitro dissolution test. The results show that the presence of the branches of PBMA decreases the hydrophilicity.",

author = "I. Echeverria and I. Silva and M. Gurruchaga and I. Go{\~n}i",

year = "2004",

language = "English",

isbn = "1877040193",

series = "Transactions - 7th World Biomaterials Congress",

pages = "1160",

booktitle = "Transactions - 7th World Biomaterials Congress",

note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

}

Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release. / Echeverria, I.; Silva, I.; Gurruchaga, M. et al.
Transactions - 7th World Biomaterials Congress. 2004. p. 1160 (Transactions - 7th World Biomaterials Congress).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release

AU - Echeverria, I.

AU - Silva, I.

AU - Gurruchaga, M.

AU - Goñi, I.

PY - 2004

Y1 - 2004

N2 - The ability of acrylic/starch graft copolymers to release drugs in the physiological medium with a release profile was demonstrated which depends on the acrylic component. The preparation of the grafted copolymer was carried out using buthyl methacrylate (BMA) (Merck), hydroxypropyl starch (HS), potato starch (S) (AVEBE) and ceric ammonium nitrate (CAN) (Fluka) as initiator. Grafting was allowed to proceed for 4h. under a constant light source using 149.62 ml of BMA. The release kinetics of the drug was subjected to in vitro dissolution test. The results show that the presence of the branches of PBMA decreases the hydrophilicity.

AB - The ability of acrylic/starch graft copolymers to release drugs in the physiological medium with a release profile was demonstrated which depends on the acrylic component. The preparation of the grafted copolymer was carried out using buthyl methacrylate (BMA) (Merck), hydroxypropyl starch (HS), potato starch (S) (AVEBE) and ceric ammonium nitrate (CAN) (Fluka) as initiator. Grafting was allowed to proceed for 4h. under a constant light source using 149.62 ml of BMA. The release kinetics of the drug was subjected to in vitro dissolution test. The results show that the presence of the branches of PBMA decreases the hydrophilicity.

UR - https://www.scopus.com/pages/publications/13844255295

M3 - Conference contribution

AN - SCOPUS:13844255295

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

SP - 1160

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Graft copolymers of starch and butyl methacrylate as biodegradable matrices for controlled drug release

Abstract

Publication series

Conference

Other files and links

Fingerprint

Cite this