TY - JOUR
T1 - Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection
AU - Han, Qingfang
AU - Pang, Jinbo
AU - Li, Yufen
AU - Sun, Baojun
AU - Ibarlucea, Bergoi
AU - Liu, Xiaoyan
AU - Gemming, Thomas
AU - Cheng, Qilin
AU - Zhang, Shu
AU - Liu, Hong
AU - Wang, Jingang
AU - Zhou, Weijia
AU - Cuniberti, Gianaurelio
AU - Rümmeli, Mark H.
N1 - Publisher Copyright:
©
PY - 2021/11/26
Y1 - 2021/11/26
N2 - The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.
AB - The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.
KW - biodevices
KW - biomarker detection
KW - circulating tumor cells
KW - early diagnosis
KW - electrochemical biosensors
KW - field-effect transistors
KW - functionalization
KW - graphene
KW - microfluidic system
KW - optical biosensors
UR - https://www.scopus.com/pages/publications/85118984824
U2 - 10.1021/acssensors.1c01172
DO - 10.1021/acssensors.1c01172
M3 - Review article
C2 - 34696585
AN - SCOPUS:85118984824
SN - 2379-3694
VL - 6
SP - 3841
EP - 3881
JO - ACS Sensors
JF - ACS Sensors
IS - 11
ER -