ICV administration of CRF blocker (CRF(9-41 δ) helical) reduces morphine withdrawal in rats

Sara Brugger; Rosa Sanchez; Arturo J. Brugger; Jose Antonio Martinez

doi:10.1016/S0278-5846(98)00039-6

ICV administration of CRF blocker (CRF(9-41 δ) helical) reduces morphine withdrawal in rats

Sara Brugger
, Rosa Sanchez
, Arturo J. Brugger
, Jose Antonio Martinez^*

^*Corresponding author for this work

Complejo Hospitalario Universitario de Albacete

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

1. The effects of CRF(9-41 δ) helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF(9-41 δ) helical 5 at 10 μg/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal syndrome was reduced by CRF(9-41 δ) helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.

Original language	English
Pages (from-to)	775-785
Number of pages	11
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/S0278-5846(98)00039-6
Publication status	Published - Jul 1998
Externally published	Yes

Keywords

CRF(9-41 δ) helical antagonist
Hypothalamo pituitary -adrenal axis
Morphine withdrawal syndrome
Opoid

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10.1016/S0278-5846(98)00039-6

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title = "ICV administration of CRF blocker (CRF(9-41 δ) helical) reduces morphine withdrawal in rats",

abstract = "1. The effects of CRF(9-41 δ) helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF(9-41 δ) helical 5 at 10 μg/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal syndrome was reduced by CRF(9-41 δ) helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.",

keywords = "CRF(9-41 δ) helical antagonist, Hypothalamo pituitary -adrenal axis, Morphine withdrawal syndrome, Opoid",

author = "Sara Brugger and Rosa Sanchez and Brugger, \{Arturo J.\} and Martinez, \{Jose Antonio\}",

year = "1998",

month = jul,

doi = "10.1016/S0278-5846(98)00039-6",

language = "English",

volume = "22",

pages = "775--785",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - ICV administration of CRF blocker (CRF(9-41 δ) helical) reduces morphine withdrawal in rats

AU - Brugger, Sara

AU - Sanchez, Rosa

AU - Brugger, Arturo J.

AU - Martinez, Jose Antonio

PY - 1998/7

Y1 - 1998/7

N2 - 1. The effects of CRF(9-41 δ) helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF(9-41 δ) helical 5 at 10 μg/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal syndrome was reduced by CRF(9-41 δ) helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.

AB - 1. The effects of CRF(9-41 δ) helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF(9-41 δ) helical 5 at 10 μg/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal syndrome was reduced by CRF(9-41 δ) helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.

KW - CRF(9-41 δ) helical antagonist

KW - Hypothalamo pituitary -adrenal axis

KW - Morphine withdrawal syndrome

KW - Opoid

UR - https://www.scopus.com/pages/publications/0032127154

U2 - 10.1016/S0278-5846(98)00039-6

DO - 10.1016/S0278-5846(98)00039-6

M3 - Article

C2 - 9723119

AN - SCOPUS:0032127154

SN - 0278-5846

VL - 22

SP - 775

EP - 785

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 5

ER -

ICV administration of CRF blocker (CRF(9-41 δ) helical) reduces morphine withdrawal in rats

Abstract

Keywords

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