Abstract
Salbutamol is a drug with a short elimination half life, and is thus a possible candidate for the development of sustained release formulations. We developed sustained release lipid matrices using Gelucires. Three different release profiles were observed : fast release, in the case of Gelucires 33/01, 35/10, 37/02, 42/12 and 44/14, with a mean dissolution time (Td50) of 6, 16, 3, 40 and 12 min; a sustained release for Gelucires 48/09, 50/13 and 53/10 with a mean dissolution time of 186, 147 and 168 min; and a slow release for Gelucires 46/07 and 50/02, with a mean dissolution time of 310 and 621 min, respectively. The percentages of salbutamol released with Gelucires 46/07 and 50/02 were below 60% of the dose. Multiple regression analysis of the hydrophilic/lipophilic balance (HLB), melting point (MP), dissolution constant (K1) and mean dissolution time (Td50) yielded the following equations: K1 = 3.13 - 0.262*HLB - 0.0648*MP + 0.00556HLB*MP, (R2 =0.88), and Td50 = - 1485 + 105*HLB + 43.2*MP - 3.03 HLB*MP, (R2 = 0.91).
| Original language | English |
|---|---|
| Pages (from-to) | 365-369 |
| Number of pages | 5 |
| Journal | S.T.P. Pharma Sciences |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - Sept 1996 |
| Externally published | Yes |
Keywords
- Capsules
- Gelucire
- Hydrophilic/lipophilic balance
- Melting point
- Release kinetics
- Salbutamol
- Sustained release