Influence of stress in the effects of morphine on pituitary-adrenocortical activity in the guinea-pig

M. L. Vargas; J. A. Martínez; T. Fuente; J. del Rio-Garcia; M. V. Milanés

doi:10.1016/0306-3623(91)90436-A

Influence of stress in the effects of morphine on pituitary-adrenocortical activity in the guinea-pig

M. L. Vargas
, J. A. Martínez
, T. Fuente
, J. del Rio-Garcia
, M. V. Milanés^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

1. 1. Modifications by stress of the effects of morphine on pituitary-adrenocortical activity were examined in the guinea-pig at different lengths of time. 2. 2. An increase in plasma cortisol but not in β-endorphin levels was obtained in guinea-pigs stressed for 60 min. 3. 3. Morphine (50 mg/kg i.p.) enhanced β-endorphin and cortisol levels 5 min after injection and decreased β-endorphin concentration 30 and 90 min after its administration. 4. 4. In stressed guinea-pigs plasma β-endorphin levels were reduced 5 min after morphine injection. 5. 5. These results indicate that stress can alter the effects of morphine on pituitary-adrenal activity in the guinea-pig and that the type of modification may be dependent on the time of the sampling.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Vascular Pharmacology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0306-3623(91)90436-A
Publication status	Published - 1991
Externally published	Yes

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title = "Influence of stress in the effects of morphine on pituitary-adrenocortical activity in the guinea-pig",

abstract = "1. 1. Modifications by stress of the effects of morphine on pituitary-adrenocortical activity were examined in the guinea-pig at different lengths of time. 2. 2. An increase in plasma cortisol but not in β-endorphin levels was obtained in guinea-pigs stressed for 60 min. 3. 3. Morphine (50 mg/kg i.p.) enhanced β-endorphin and cortisol levels 5 min after injection and decreased β-endorphin concentration 30 and 90 min after its administration. 4. 4. In stressed guinea-pigs plasma β-endorphin levels were reduced 5 min after morphine injection. 5. 5. These results indicate that stress can alter the effects of morphine on pituitary-adrenal activity in the guinea-pig and that the type of modification may be dependent on the time of the sampling.",

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doi = "10.1016/0306-3623(91)90436-A",

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T1 - Influence of stress in the effects of morphine on pituitary-adrenocortical activity in the guinea-pig

AU - Vargas, M. L.

AU - Martínez, J. A.

AU - Fuente, T.

AU - del Rio-Garcia, J.

AU - Milanés, M. V.

PY - 1991

Y1 - 1991

N2 - 1. 1. Modifications by stress of the effects of morphine on pituitary-adrenocortical activity were examined in the guinea-pig at different lengths of time. 2. 2. An increase in plasma cortisol but not in β-endorphin levels was obtained in guinea-pigs stressed for 60 min. 3. 3. Morphine (50 mg/kg i.p.) enhanced β-endorphin and cortisol levels 5 min after injection and decreased β-endorphin concentration 30 and 90 min after its administration. 4. 4. In stressed guinea-pigs plasma β-endorphin levels were reduced 5 min after morphine injection. 5. 5. These results indicate that stress can alter the effects of morphine on pituitary-adrenal activity in the guinea-pig and that the type of modification may be dependent on the time of the sampling.

AB - 1. 1. Modifications by stress of the effects of morphine on pituitary-adrenocortical activity were examined in the guinea-pig at different lengths of time. 2. 2. An increase in plasma cortisol but not in β-endorphin levels was obtained in guinea-pigs stressed for 60 min. 3. 3. Morphine (50 mg/kg i.p.) enhanced β-endorphin and cortisol levels 5 min after injection and decreased β-endorphin concentration 30 and 90 min after its administration. 4. 4. In stressed guinea-pigs plasma β-endorphin levels were reduced 5 min after morphine injection. 5. 5. These results indicate that stress can alter the effects of morphine on pituitary-adrenal activity in the guinea-pig and that the type of modification may be dependent on the time of the sampling.

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DO - 10.1016/0306-3623(91)90436-A

M3 - Article

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AN - SCOPUS:0026078150

SN - 0306-3623

VL - 22

SP - 223

EP - 226

JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 2

ER -

Influence of stress in the effects of morphine on pituitary-adrenocortical activity in the guinea-pig

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