Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED)

F. Chiavaioli; A. Giannetti; S. Tombelli; C. Trono; I. Del Villar; I. R. Matias; P. Zubiate; C. R. Zamarreño; F. J. Arregui; F. Baldini

doi:10.1007/978-3-030-37558-4_49

Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED)

F. Chiavaioli^*
, A. Giannetti
, S. Tombelli
, C. Trono
, I. Del Villar
, I. R. Matias
, P. Zubiate
, C. R. Zamarreño
, F. J. Arregui
, F. Baldini

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

The combination of optical fibre-based biosensors with nanotechnologies is providing the opportunity for the development of in situ, portable, lightweight, versatile and high-sensitivity optical sensing platforms. We report on the generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick SnO₂ film on optical fibres. This allows measuring precisely and accurately the changes in refractive index of the fibre-surrounding medium with very high sensitivity compared to other optical technology platforms, such as long period grating or surface plasmon resonance. This approach, mixed with the use of specialty fiber structures such as D-shaped fibres, allows improving the light-matter interaction in strong way. Different imaging systems, i.e. SEM and TEM along with X-EDS tool, have been used to study the optical features of the fiber coating. The shift of the LMR has been monitored in real-time thanks to conventional wavelength interrogation system and ad hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in human serum. The biosensor reusability has been also tested by using a solution of sodium dodecyl sulphate.

Original language	English
Title of host publication	Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference
Editors	G. Di Francia, B. Alfano, S. De Vito, E. Esposito, G. Fattoruso, F. Formisano, E. Massera, M.L. Miglietta, T. Polichetti, C. Di Natale
Publisher	Springer
Pages	321-327
Number of pages	7
ISBN (Print)	9783030375577
DOIs	https://doi.org/10.1007/978-3-030-37558-4_49
Publication status	Published - 2020
Externally published	Yes
Event	20th AISEM National Conference on Sensors and Microsystems, 2019 - Naples, Italy Duration: 11 Feb 2019 → 13 Feb 2019

Publication series

Name	Lecture Notes in Electrical Engineering
Volume	629
ISSN (Print)	1876-1100
ISSN (Electronic)	1876-1119

Conference

Conference	20th AISEM National Conference on Sensors and Microsystems, 2019
Country/Territory	Italy
City	Naples
Period	11/02/19 → 13/02/19

Keywords

Femtomolar concentration
In-fiber optical sensing platform
Lossy mode resonance
Nanofilm deposition
Reusability

Access to Document

10.1007/978-3-030-37558-4_49

Cite this

Chiavaioli, F., Giannetti, A., Tombelli, S., Trono, C., Del Villar, I., Matias, I. R., Zubiate, P., Zamarreño, C. R., Arregui, F. J., & Baldini, F. (2020). Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED). In G. Di Francia, B. Alfano, S. De Vito, E. Esposito, G. Fattoruso, F. Formisano, E. Massera, M. L. Miglietta, T. Polichetti, & C. Di Natale (Eds.), Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference (pp. 321-327). (Lecture Notes in Electrical Engineering; Vol. 629). Springer. https://doi.org/10.1007/978-3-030-37558-4_49

Chiavaioli, F. ; Giannetti, A. ; Tombelli, S. et al. / Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED). Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference. editor / G. Di Francia ; B. Alfano ; S. De Vito ; E. Esposito ; G. Fattoruso ; F. Formisano ; E. Massera ; M.L. Miglietta ; T. Polichetti ; C. Di Natale. Springer, 2020. pp. 321-327 (Lecture Notes in Electrical Engineering).

@inproceedings{149baabb30264eb5bf50e3fe94c3fabd,

title = "Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED)",

abstract = "The combination of optical fibre-based biosensors with nanotechnologies is providing the opportunity for the development of in situ, portable, lightweight, versatile and high-sensitivity optical sensing platforms. We report on the generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick SnO2 film on optical fibres. This allows measuring precisely and accurately the changes in refractive index of the fibre-surrounding medium with very high sensitivity compared to other optical technology platforms, such as long period grating or surface plasmon resonance. This approach, mixed with the use of specialty fiber structures such as D-shaped fibres, allows improving the light-matter interaction in strong way. Different imaging systems, i.e. SEM and TEM along with X-EDS tool, have been used to study the optical features of the fiber coating. The shift of the LMR has been monitored in real-time thanks to conventional wavelength interrogation system and ad hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in human serum. The biosensor reusability has been also tested by using a solution of sodium dodecyl sulphate.",

keywords = "Femtomolar concentration, In-fiber optical sensing platform, Lossy mode resonance, Nanofilm deposition, Reusability",

author = "F. Chiavaioli and A. Giannetti and S. Tombelli and C. Trono and \{Del Villar\}, I. and Matias, \{I. R.\} and P. Zubiate and Zamarre{\~n}o, \{C. R.\} and Arregui, \{F. J.\} and F. Baldini",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.; 20th AISEM National Conference on Sensors and Microsystems, 2019 ; Conference date: 11-02-2019 Through 13-02-2019",

year = "2020",

doi = "10.1007/978-3-030-37558-4\_49",

language = "English",

isbn = "9783030375577",

series = "Lecture Notes in Electrical Engineering",

publisher = "Springer",

pages = "321--327",

editor = "\{Di Francia\}, G. and B. Alfano and \{De Vito\}, S. and E. Esposito and G. Fattoruso and F. Formisano and E. Massera and M.L. Miglietta and T. Polichetti and \{Di Natale\}, C.",

booktitle = "Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference",

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Chiavaioli, F, Giannetti, A, Tombelli, S, Trono, C, Del Villar, I, Matias, IR, Zubiate, P, Zamarreño, CR, Arregui, FJ & Baldini, F 2020, Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED). in G Di Francia, B Alfano, S De Vito, E Esposito, G Fattoruso, F Formisano, E Massera, ML Miglietta, T Polichetti & C Di Natale (eds), Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference. Lecture Notes in Electrical Engineering, vol. 629, Springer, pp. 321-327, 20th AISEM National Conference on Sensors and Microsystems, 2019, Naples, Italy, 11/02/19. https://doi.org/10.1007/978-3-030-37558-4_49

Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED). / Chiavaioli, F.; Giannetti, A.; Tombelli, S. et al.
Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference. ed. / G. Di Francia; B. Alfano; S. De Vito; E. Esposito; G. Fattoruso; F. Formisano; E. Massera; M.L. Miglietta; T. Polichetti; C. Di Natale. Springer, 2020. p. 321-327 (Lecture Notes in Electrical Engineering; Vol. 629).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED)

AU - Chiavaioli, F.

AU - Giannetti, A.

AU - Tombelli, S.

AU - Trono, C.

AU - Del Villar, I.

AU - Matias, I. R.

AU - Zubiate, P.

AU - Zamarreño, C. R.

AU - Arregui, F. J.

AU - Baldini, F.

PY - 2020

Y1 - 2020

N2 - The combination of optical fibre-based biosensors with nanotechnologies is providing the opportunity for the development of in situ, portable, lightweight, versatile and high-sensitivity optical sensing platforms. We report on the generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick SnO2 film on optical fibres. This allows measuring precisely and accurately the changes in refractive index of the fibre-surrounding medium with very high sensitivity compared to other optical technology platforms, such as long period grating or surface plasmon resonance. This approach, mixed with the use of specialty fiber structures such as D-shaped fibres, allows improving the light-matter interaction in strong way. Different imaging systems, i.e. SEM and TEM along with X-EDS tool, have been used to study the optical features of the fiber coating. The shift of the LMR has been monitored in real-time thanks to conventional wavelength interrogation system and ad hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in human serum. The biosensor reusability has been also tested by using a solution of sodium dodecyl sulphate.

AB - The combination of optical fibre-based biosensors with nanotechnologies is providing the opportunity for the development of in situ, portable, lightweight, versatile and high-sensitivity optical sensing platforms. We report on the generation of lossy mode resonances (LMRs) by means of the deposition of nm-thick SnO2 film on optical fibres. This allows measuring precisely and accurately the changes in refractive index of the fibre-surrounding medium with very high sensitivity compared to other optical technology platforms, such as long period grating or surface plasmon resonance. This approach, mixed with the use of specialty fiber structures such as D-shaped fibres, allows improving the light-matter interaction in strong way. Different imaging systems, i.e. SEM and TEM along with X-EDS tool, have been used to study the optical features of the fiber coating. The shift of the LMR has been monitored in real-time thanks to conventional wavelength interrogation system and ad hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in human serum. The biosensor reusability has been also tested by using a solution of sodium dodecyl sulphate.

KW - Femtomolar concentration

KW - In-fiber optical sensing platform

KW - Lossy mode resonance

KW - Nanofilm deposition

KW - Reusability

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U2 - 10.1007/978-3-030-37558-4_49

DO - 10.1007/978-3-030-37558-4_49

M3 - Conference contribution

AN - SCOPUS:85081590986

SN - 9783030375577

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BT - Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference

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A2 - Alfano, B.

A2 - De Vito, S.

A2 - Esposito, E.

A2 - Fattoruso, G.

A2 - Formisano, F.

A2 - Massera, E.

A2 - Miglietta, M.L.

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A2 - Di Natale, C.

PB - Springer

T2 - 20th AISEM National Conference on Sensors and Microsystems, 2019

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ER -

Chiavaioli F, Giannetti A, Tombelli S, Trono C, Del Villar I, Matias IR et al. Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED). In Di Francia G, Alfano B, De Vito S, Esposito E, Fattoruso G, Formisano F, Massera E, Miglietta ML, Polichetti T, Di Natale C, editors, Sensors and Microsystems - Proceedings of the 20th AISEM 2019 National Conference. Springer. 2020. p. 321-327. (Lecture Notes in Electrical Engineering). doi: 10.1007/978-3-030-37558-4_49

Lossy Mode Resonance Enabling Ultra-Low Detection Limit for Fibre-Optic Biosensors (INVITED)

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