Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

J. I. Lombrana; F. Mijangos; F. Varona; M. C. Villaran

Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

J. I. Lombrana, F. Mijangos, F. Varona, M. C. Villaran

Healthy food

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

Original language	English
Title of host publication	Unknown Host Publication Title
Publisher	Amsterdam, The Netherlands, Elsevier Science Publishers
ISBN (Print)	0444893520, 9780444893529
Publication status	Published - 1991

Cite this

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title = "Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature",

abstract = "A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)",

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T1 - Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

AU - Lombrana, J. I.

AU - Mijangos, F.

AU - Varona, F.

AU - Villaran, M. C.

PY - 1991

Y1 - 1991

N2 - A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

AB - A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

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M3 - Chapter

AN - SCOPUS:85041153390

SN - 0444893520

SN - 9780444893529

BT - Unknown Host Publication Title

PB - Amsterdam, The Netherlands, Elsevier Science Publishers

ER -

Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

Abstract

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