TY - GEN
T1 - Osteoblast response to single wall carbon nanotube-PLLA composites
AU - Annaz, B.
AU - Reid, B.
AU - Olalde, B.
AU - Jurado, M. J.
AU - Alava, J. I.
AU - McCaig, C. D.
AU - Gibson, I. R.
PY - 2008
Y1 - 2008
N2 - This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.
AB - This study showed that incorporation of single-walled carbon nanotubes (1wt%) in to PLLA polymer resulted in a large decrease in resistivity, but did not appear to affect the growth and viability of osteoblast-like cells. Also, incorporation of SWCNTs resulted in no significant difference in alkaline phosphatase activity, an important early-stage marker of osteogenic differentiation, of BMSC. These initial studies suggest that SWCNTs did not have a negative effect on cell behaviour, compared to results reported for MWCNT [2]; this could be related to the purity of CNTs used in the present study. Further, long term studies are required to determine if there is a toxic response to the SWCNTs as the PLLA degrades.
UR - http://www.scopus.com/inward/record.url?scp=84869019451&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84869019451
SN - 9781615670802
T3 - 8th World Biomaterials Congress 2008
SP - 647
BT - 8th World Biomaterials Congress 2008
T2 - 8th World Biomaterials Congress 2008, WBC 2008
Y2 - 28 May 2008 through 1 June 2008
ER -