TY - JOUR
T1 - Pectin-cellulose hydrogel, silk fibroin and magnesium hydroxide nanoparticles hybrid nanocomposites for biomedical applications
AU - Eivazzadeh-Keihan, Reza
AU - Ahmadpour, Farnoush
AU - Aliabadi, Hooman Aghamirza Moghim
AU - Radinekiyan, Fateme
AU - Maleki, Ali
AU - Madanchi, Hamid
AU - Mahdavi, Mohammad
AU - Shalan, Ahmed Esmail
AU - Lanceros-Méndez, Senentxu
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Natural polymers are at the center of materials development for biomedical and biotechnological applications based on their biocompatibility, low-toxicity and biodegradability. In this study, a novel nanobiocomposite based on cross-linked pectin-cellulose hydrogel, silk fibroin, and Mg(OH)2 nanoparticles was designed and synthesized. After extensive physical-chemical characterization, the biological response of pectin-cellulose/silk fibroin/Mg(OH)2 nanobiocomposite scaffolds was evaluated by cell viability, red blood cells hemolytic and anti-biofilm assays. After 3 days and 7 days, the cell viability of this nanobiocomposite scaffold was 65.5% and 60.5% respectively. The hemolytic effect was below 20%. Furthermore, the presence of silk fibroin and Mg(OH)2 nanoparticles allowed to enhance the anti-biofilm activity, inhibiting the P. aeruginosa biofilm formation.
AB - Natural polymers are at the center of materials development for biomedical and biotechnological applications based on their biocompatibility, low-toxicity and biodegradability. In this study, a novel nanobiocomposite based on cross-linked pectin-cellulose hydrogel, silk fibroin, and Mg(OH)2 nanoparticles was designed and synthesized. After extensive physical-chemical characterization, the biological response of pectin-cellulose/silk fibroin/Mg(OH)2 nanobiocomposite scaffolds was evaluated by cell viability, red blood cells hemolytic and anti-biofilm assays. After 3 days and 7 days, the cell viability of this nanobiocomposite scaffold was 65.5% and 60.5% respectively. The hemolytic effect was below 20%. Furthermore, the presence of silk fibroin and Mg(OH)2 nanoparticles allowed to enhance the anti-biofilm activity, inhibiting the P. aeruginosa biofilm formation.
KW - Biocompatibility
KW - Mg(OH) nanoparticles
KW - Nanobiocomposite
KW - Pectin-cellulose hydrogel
KW - Silk fibroin
UR - https://www.scopus.com/pages/publications/85116368117
U2 - 10.1016/j.ijbiomac.2021.09.099
DO - 10.1016/j.ijbiomac.2021.09.099
M3 - Article
C2 - 34571124
AN - SCOPUS:85116368117
SN - 0141-8130
VL - 192
SP - 7
EP - 15
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -