pKa determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry

E. Cagigal; L. González; R. M. Alonso; R. M. Jiménez

doi:10.1016/S0731-7085(01)00413-7

pK_a determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry

E. Cagigal
, L. González
, R. M. Alonso
, R. M. Jiménez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

The acid-base equilibrium constants of a new family of antihypertensive drugs, the angiotensin II receptor antagonists (ARA II), Losartan, Irbesartan, Valsartan, Candesartan cilexetil, its metabolite Candesartan M1 and Telmisartan were determined by spectrofluorimetry. Relative fluorescent intensity (I_F,rel)-pH data were treated by graphical (derivatives and curve-fitting) and numerical methods (LETAGROP SPEFO). The resultant pK_a values at an ionic strength of 0.5 M were (3.15 ± 0.07) for Losartan, (4.70 ± 0.06) for Irbesartan, (4.90 ± 0.09) for Valsartan, (6.0 ± 0.1) for Candesartan cilexetil, (3.9 ± 0.1) for Candesartan M1, and (4.45 ± 0.09) for Telmisartan.

Original language	English
Pages (from-to)	477-486
Number of pages	10
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/S0731-7085(01)00413-7
Publication status	Published - 2001
Externally published	Yes

Keywords

Acid-base equilibrium constants
Angiotensin II receptor antagonists
Antihypertensive drugs
Spectrofluorimetry

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10.1016/S0731-7085(01)00413-7

Cite this

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title = "pKa determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry",

abstract = "The acid-base equilibrium constants of a new family of antihypertensive drugs, the angiotensin II receptor antagonists (ARA II), Losartan, Irbesartan, Valsartan, Candesartan cilexetil, its metabolite Candesartan M1 and Telmisartan were determined by spectrofluorimetry. Relative fluorescent intensity (IF,rel)-pH data were treated by graphical (derivatives and curve-fitting) and numerical methods (LETAGROP SPEFO). The resultant pKa values at an ionic strength of 0.5 M were (3.15 ± 0.07) for Losartan, (4.70 ± 0.06) for Irbesartan, (4.90 ± 0.09) for Valsartan, (6.0 ± 0.1) for Candesartan cilexetil, (3.9 ± 0.1) for Candesartan M1, and (4.45 ± 0.09) for Telmisartan.",

keywords = "Acid-base equilibrium constants, Angiotensin II receptor antagonists, Antihypertensive drugs, Spectrofluorimetry",

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year = "2001",

doi = "10.1016/S0731-7085(01)00413-7",

language = "English",

volume = "26",

pages = "477--486",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

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TY - JOUR

T1 - pKa determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry

AU - Cagigal, E.

AU - González, L.

AU - Alonso, R. M.

AU - Jiménez, R. M.

PY - 2001

Y1 - 2001

N2 - The acid-base equilibrium constants of a new family of antihypertensive drugs, the angiotensin II receptor antagonists (ARA II), Losartan, Irbesartan, Valsartan, Candesartan cilexetil, its metabolite Candesartan M1 and Telmisartan were determined by spectrofluorimetry. Relative fluorescent intensity (IF,rel)-pH data were treated by graphical (derivatives and curve-fitting) and numerical methods (LETAGROP SPEFO). The resultant pKa values at an ionic strength of 0.5 M were (3.15 ± 0.07) for Losartan, (4.70 ± 0.06) for Irbesartan, (4.90 ± 0.09) for Valsartan, (6.0 ± 0.1) for Candesartan cilexetil, (3.9 ± 0.1) for Candesartan M1, and (4.45 ± 0.09) for Telmisartan.

AB - The acid-base equilibrium constants of a new family of antihypertensive drugs, the angiotensin II receptor antagonists (ARA II), Losartan, Irbesartan, Valsartan, Candesartan cilexetil, its metabolite Candesartan M1 and Telmisartan were determined by spectrofluorimetry. Relative fluorescent intensity (IF,rel)-pH data were treated by graphical (derivatives and curve-fitting) and numerical methods (LETAGROP SPEFO). The resultant pKa values at an ionic strength of 0.5 M were (3.15 ± 0.07) for Losartan, (4.70 ± 0.06) for Irbesartan, (4.90 ± 0.09) for Valsartan, (6.0 ± 0.1) for Candesartan cilexetil, (3.9 ± 0.1) for Candesartan M1, and (4.45 ± 0.09) for Telmisartan.

KW - Acid-base equilibrium constants

KW - Angiotensin II receptor antagonists

KW - Antihypertensive drugs

KW - Spectrofluorimetry

UR - https://www.scopus.com/pages/publications/0034897686

U2 - 10.1016/S0731-7085(01)00413-7

DO - 10.1016/S0731-7085(01)00413-7

M3 - Article

C2 - 11489393

AN - SCOPUS:0034897686

SN - 0731-7085

VL - 26

SP - 477

EP - 486

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 3

ER -

pK_a determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry

Abstract

Keywords

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