TY - JOUR
T1 - Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
AU - Everson, Todd M.
AU - Vives-Usano, Marta
AU - Seyve, Emie
AU - Cardenas, Andres
AU - Lacasaña, Marina
AU - Craig, Jeffrey M.
AU - Lesseur, Corina
AU - Baker, Emily R.
AU - Fernandez-Jimenez, Nora
AU - Heude, Barbara
AU - Perron, Patrice
AU - Gónzalez-Alzaga, Beatriz
AU - Halliday, Jane
AU - Deyssenroth, Maya A.
AU - Karagas, Margaret R.
AU - Íñiguez, Carmen
AU - Bouchard, Luigi
AU - Carmona-Sáez, Pedro
AU - Loke, Yuk J.
AU - Hao, Ke
AU - Belmonte, Thalia
AU - Charles, Marie A.
AU - Martorell-Marugán, Jordi
AU - Muggli, Evelyne
AU - Chen, Jia
AU - Fernández, Mariana F.
AU - Tost, Jorg
AU - Gómez-Martín, Antonio
AU - London, Stephanie J.
AU - Sunyer, Jordi
AU - Marsit, Carmen J.
AU - Lepeule, Johanna
AU - Hivert, Marie France
AU - Bustamante, Mariona
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
AB - Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
UR - https://www.scopus.com/pages/publications/85113380691
U2 - 10.1038/s41467-021-24558-y
DO - 10.1038/s41467-021-24558-y
M3 - Article
C2 - 34429407
AN - SCOPUS:85113380691
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5095
ER -