TY - GEN
T1 - Poly(dimethylsiloxane) photonic microbioreactors and multiple internal reflection systems for real time cell screening
AU - Ortiz, Pedro
AU - Demming, Stefanie
AU - Fernández-Rosas, Elisabet
AU - Ibarlucea, Bergoi
AU - Vila-Planas, Jordi
AU - Büttgenbach, Stephanus
AU - Llobera, Andreu
PY - 2011
Y1 - 2011
N2 - In this paper two different photonic lab-on-a-chip devices for real-time cell screening are presented. We discuss, in parallel, screening of cell viability and cell count using a multiple total internal reflection (MIR) system, and a microbioreactor (MBR) for continuous cell culture screening. Each device takes advantage, in different ways, of the enhanced light-analyte interaction provided by the full-field approach. Their performance and how they represent an improvement to current methods, are also discussed herein. Both devices integrate photonic components and are fabricated by soft lithography (PDMS) replica molding of SU-8 masters, thus making them low-cost and easily mass produced.
AB - In this paper two different photonic lab-on-a-chip devices for real-time cell screening are presented. We discuss, in parallel, screening of cell viability and cell count using a multiple total internal reflection (MIR) system, and a microbioreactor (MBR) for continuous cell culture screening. Each device takes advantage, in different ways, of the enhanced light-analyte interaction provided by the full-field approach. Their performance and how they represent an improvement to current methods, are also discussed herein. Both devices integrate photonic components and are fabricated by soft lithography (PDMS) replica molding of SU-8 masters, thus making them low-cost and easily mass produced.
KW - Biosensors
KW - Cell screening
KW - Lab-on-a-chip
KW - Microbioreactors
KW - Optofluidics
UR - https://www.scopus.com/pages/publications/79960509820
U2 - 10.1117/12.889671
DO - 10.1117/12.889671
M3 - Conference contribution
AN - SCOPUS:79960509820
SN - 9780819486554
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Smart Sensors, Actuators, and MEMS V
T2 - Smart Sensors, Actuators, and MEMS V
Y2 - 18 April 2011 through 20 April 2011
ER -