TY - JOUR
T1 - Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women
AU - Pérez-Castrillón, José Luis
AU - Justo, Isabel
AU - Silva, Jesús
AU - Sanz, Alberto
AU - Martín-Escudero, Juan Carlos
AU - Igea, Rosa
AU - Escudero, Pilar
AU - Pueyo, Carol
AU - Diaz, Cristina
AU - Hernández, Gonzalo
AU - Dueñas, Antonio
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.
AB - Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.
KW - ACE I/D polymorphism
KW - Bone mineral density
KW - Calcium excretion
KW - Hypertension
KW - Women
UR - https://www.scopus.com/pages/publications/0347297216
U2 - 10.1016/S0895-7061(02)03263-6
DO - 10.1016/S0895-7061(02)03263-6
M3 - Article
C2 - 12620703
AN - SCOPUS:0347297216
SN - 0895-7061
VL - 16
SP - 233
EP - 235
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 3
ER -