Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women

José Luis Pérez-Castrillón; Isabel Justo; Jesús Silva; Alberto Sanz; Juan Carlos Martín-Escudero; Rosa Igea; Pilar Escudero; Carol Pueyo; Cristina Diaz; Gonzalo Hernández; Antonio Dueñas

doi:10.1016/S0895-7061(02)03263-6

Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women

José Luis Pérez-Castrillón^*
, Isabel Justo
, Jesús Silva
, Alberto Sanz
, Juan Carlos Martín-Escudero
, Rosa Igea
, Pilar Escudero
, Carol Pueyo
, Cristina Diaz
, Gonzalo Hernández
, Antonio Dueñas

^*Corresponding author for this work

Hospital Universitario Río Hortega
University of Valladolid
Pfizer, SLU

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.

Original language	English
Pages (from-to)	233-235
Number of pages	3
Journal	American Journal of Hypertension
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/S0895-7061(02)03263-6
Publication status	Published - 1 Mar 2003
Externally published	Yes

Keywords

ACE I/D polymorphism
Bone mineral density
Calcium excretion
Hypertension
Women

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10.1016/S0895-7061(02)03263-6

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Pérez-Castrillón, J. L., Justo, I., Silva, J., Sanz, A., Martín-Escudero, J. C., Igea, R., Escudero, P., Pueyo, C., Diaz, C., Hernández, G., & Dueñas, A. (2003). Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women. American Journal of Hypertension, 16(3), 233-235. https://doi.org/10.1016/S0895-7061(02)03263-6

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title = "Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women",

abstract = "Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.",

keywords = "ACE I/D polymorphism, Bone mineral density, Calcium excretion, Hypertension, Women",

author = "P{\'e}rez-Castrill{\'o}n, \{Jos{\'e} Luis\} and Isabel Justo and Jes{\'u}s Silva and Alberto Sanz and Mart{\'i}n-Escudero, \{Juan Carlos\} and Rosa Igea and Pilar Escudero and Carol Pueyo and Cristina Diaz and Gonzalo Hern{\'a}ndez and Antonio Due{\~n}as",

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doi = "10.1016/S0895-7061(02)03263-6",

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Pérez-Castrillón, JL, Justo, I, Silva, J, Sanz, A, Martín-Escudero, JC, Igea, R, Escudero, P, Pueyo, C, Diaz, C, Hernández, G & Dueñas, A 2003, 'Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women', American Journal of Hypertension, vol. 16, no. 3, pp. 233-235. https://doi.org/10.1016/S0895-7061(02)03263-6

TY - JOUR

T1 - Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women

AU - Pérez-Castrillón, José Luis

AU - Justo, Isabel

AU - Silva, Jesús

AU - Sanz, Alberto

AU - Martín-Escudero, Juan Carlos

AU - Igea, Rosa

AU - Escudero, Pilar

AU - Pueyo, Carol

AU - Diaz, Cristina

AU - Hernández, Gonzalo

AU - Dueñas, Antonio

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.

AB - Background: The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women. Methods: Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction. Results: Women with II genotype showed a higher intact parathyroid hormone (76 ± 33 v 55 ± 27 pg/mL and 52 ± 26 pg/mL, P = .034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 ± 0.08 v 1.051 ± 0.16 pg/mL and 1.053 ± 0.16 pg/mL). Conclusion: The ACE polymorphism could be one of the factors causing bone mass variations.

KW - ACE I/D polymorphism

KW - Bone mineral density

KW - Calcium excretion

KW - Hypertension

KW - Women

UR - https://www.scopus.com/pages/publications/0347297216

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DO - 10.1016/S0895-7061(02)03263-6

M3 - Article

C2 - 12620703

AN - SCOPUS:0347297216

SN - 0895-7061

VL - 16

SP - 233

EP - 235

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 3

ER -

Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women

Abstract

Keywords

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