Simulation and design of beating profiles in beat controlled freeze-drying or pharmaceuticals in vials by the application of a sublimation cylindrical model

J. I. Lombrana; C. De Elvira; M. C. Villaran

doi:10.1080/07373939308916804

Simulation and design of beating profiles in beat controlled freeze-drying or pharmaceuticals in vials by the application of a sublimation cylindrical model

J. I. Lombrana
, C. De Elvira
, M. C. Villaran

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.

Original language	English
Pages (from-to)	85-102
Number of pages	18
Journal	Drying Technology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/07373939308916804
Publication status	Published - 1993
Externally published	Yes

Keywords

Freeze-drying
heating strategies
modelling
operating conditions

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10.1080/07373939308916804

Cite this

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abstract = "A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.",

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AU - De Elvira, C.

AU - Villaran, M. C.

PY - 1993

Y1 - 1993

N2 - A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.

AB - A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.

KW - Freeze-drying

KW - heating strategies

KW - modelling

KW - operating conditions

UR - https://www.scopus.com/pages/publications/0027289849

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DO - 10.1080/07373939308916804

M3 - Article

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Simulation and design of beating profiles in beat controlled freeze-drying or pharmaceuticals in vials by the application of a sublimation cylindrical model

Abstract

Keywords

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