Simulation and design of beating profiles in heat controlled freeze-drying of pharmaceuticals in vials by the application of a sublimation semisphsrical model

J. I. Lombrana; C. De Elvira; M. C. Villaran; J. Izcara

doi:10.1080/07373939308916839

Simulation and design of beating profiles in heat controlled freeze-drying of pharmaceuticals in vials by the application of a sublimation semisphsrical model

J. I. Lombrana
, C. De Elvira^*
, M. C. Villaran
, J. Izcara

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The freeze-drying of a certain pharmaceutical contained in vials in industrial like conditions has been described by a sublimation model under analogous semispherical configuration. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to obtain orientative simulated results in heating strategies analysis in order to reduce drying time.

Original language	English
Pages (from-to)	471-487
Number of pages	17
Journal	Drying Technology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1080/07373939308916839
Publication status	Published - 1 Jan 1993
Externally published	Yes

Keywords

and Phrases
Freeze-drying
heating strategies
modelling
operating conditions

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10.1080/07373939308916839

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abstract = "The freeze-drying of a certain pharmaceutical contained in vials in industrial like conditions has been described by a sublimation model under analogous semispherical configuration. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to obtain orientative simulated results in heating strategies analysis in order to reduce drying time.",

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AU - Villaran, M. C.

AU - Izcara, J.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The freeze-drying of a certain pharmaceutical contained in vials in industrial like conditions has been described by a sublimation model under analogous semispherical configuration. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to obtain orientative simulated results in heating strategies analysis in order to reduce drying time.

AB - The freeze-drying of a certain pharmaceutical contained in vials in industrial like conditions has been described by a sublimation model under analogous semispherical configuration. Several operating strategies were proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to obtain orientative simulated results in heating strategies analysis in order to reduce drying time.

KW - and Phrases

KW - Freeze-drying

KW - heating strategies

KW - modelling

KW - operating conditions

UR - https://www.scopus.com/pages/publications/0027592562

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ER -

Simulation and design of beating profiles in heat controlled freeze-drying of pharmaceuticals in vials by the application of a sublimation semisphsrical model

Abstract

Keywords

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