Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs

M. Victoria Milanés; Jesús del Rio-García; Teodomiro Fuente; J. Antonio Martínez; M. Luisa Vargas

doi:10.1016/0306-3623(90)90717-Z

Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs

M. Victoria Milanés^*
, Jesús del Rio-García
, Teodomiro Fuente
, J. Antonio Martínez
, M. Luisa Vargas

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.

Original language	English
Pages (from-to)	569-571
Number of pages	3
Journal	General Pharmacology: The Vascular System
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(90)90717-Z
Publication status	Published - 1990
Externally published	Yes

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title = "Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs",

abstract = "1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.",

author = "Milan{\'e}s, \{M. Victoria\} and \{del Rio-Garc{\'i}a\}, Jes{\'u}s and Teodomiro Fuente and Mart{\'i}nez, \{J. Antonio\} and Vargas, \{M. Luisa\}",

year = "1990",

doi = "10.1016/0306-3623(90)90717-Z",

language = "English",

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journal = "General Pharmacology: The Vascular System",

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TY - JOUR

T1 - Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs

AU - Milanés, M. Victoria

AU - del Rio-García, Jesús

AU - Fuente, Teodomiro

AU - Martínez, J. Antonio

AU - Vargas, M. Luisa

PY - 1990

Y1 - 1990

N2 - 1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.

AB - 1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.

UR - https://www.scopus.com/pages/publications/0025311465

U2 - 10.1016/0306-3623(90)90717-Z

DO - 10.1016/0306-3623(90)90717-Z

M3 - Article

C2 - 2143160

AN - SCOPUS:0025311465

SN - 0306-3623

VL - 21

SP - 569

EP - 571

JO - General Pharmacology: The Vascular System

JF - General Pharmacology: The Vascular System

IS - 4

ER -

Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs

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