TY - JOUR
T1 - Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs
AU - Milanés, M. Victoria
AU - del Rio-García, Jesús
AU - Fuente, Teodomiro
AU - Martínez, J. Antonio
AU - Vargas, M. Luisa
PY - 1990
Y1 - 1990
N2 - 1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.
AB - 1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.
UR - https://www.scopus.com/pages/publications/0025311465
U2 - 10.1016/0306-3623(90)90717-Z
DO - 10.1016/0306-3623(90)90717-Z
M3 - Article
C2 - 2143160
AN - SCOPUS:0025311465
SN - 0306-3623
VL - 21
SP - 569
EP - 571
JO - Vascular Pharmacology
JF - Vascular Pharmacology
IS - 4
ER -