Structure-properties relationship of chitosan/collagen films with potential for biomedical applications

Mireia Andonegi; Kevin Las Heras; Edorta Santos-Vizcaíno; Manoli Igartua; Rosa Maria Hernandez; Koro de la Caba; Pedro Guerrero

doi:10.1016/j.carbpol.2020.116159

Structure-properties relationship of chitosan/collagen films with potential for biomedical applications

Mireia Andonegi
, Kevin Las Heras
, Edorta Santos-Vizcaíno
, Manoli Igartua
, Rosa Maria Hernandez
, Koro de la Caba^*
, Pedro Guerrero

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

162 Citations (Scopus)

Abstract

Chitosan/collagen films were developed and characterized in order to assess the suitability of these films for biomedical applications. Hence, physicochemical, thermal, barrier and mechanical properties were analyzed and related to the film structure, which showed the prevalence of the triple helix of native collagen after the addition of chitosan. Furthermore, collagen fiber diameter changed from 3.9 ± 0.6 μm, for collagen films without chitosan, to 1.8 ± 0.5 μm, for collagen films with low molecular weight chitosan. These results suggested interactions between collagen and chitosan molecules, as observed by Fourier transform infrared (FTIR) analysis. Regarding film barrier properties, chitosan/collagen films showed a water vapor transmission rate around 1174 g m⁻² day⁻¹, suitable for biomedical applications such as wound healing. Additionally, biological tests confirmed that the chitosan/collagen films developed are suitable for biomedical applications.

Original language	English
Article number	116159
Journal	Carbohydrate Polymers
Volume	237
DOIs	https://doi.org/10.1016/j.carbpol.2020.116159
Publication status	Published - 1 Jun 2020
Externally published	Yes

Keywords

Biomaterial
Chitosan
Collagen
Film
Triple helix

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10.1016/j.carbpol.2020.116159

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title = "Structure-properties relationship of chitosan/collagen films with potential for biomedical applications",

abstract = "Chitosan/collagen films were developed and characterized in order to assess the suitability of these films for biomedical applications. Hence, physicochemical, thermal, barrier and mechanical properties were analyzed and related to the film structure, which showed the prevalence of the triple helix of native collagen after the addition of chitosan. Furthermore, collagen fiber diameter changed from 3.9 ± 0.6 μm, for collagen films without chitosan, to 1.8 ± 0.5 μm, for collagen films with low molecular weight chitosan. These results suggested interactions between collagen and chitosan molecules, as observed by Fourier transform infrared (FTIR) analysis. Regarding film barrier properties, chitosan/collagen films showed a water vapor transmission rate around 1174 g m−2 day−1, suitable for biomedical applications such as wound healing. Additionally, biological tests confirmed that the chitosan/collagen films developed are suitable for biomedical applications.",

keywords = "Biomaterial, Chitosan, Collagen, Film, Triple helix",

author = "Mireia Andonegi and Heras, \{Kevin Las\} and Edorta Santos-Vizca{\'i}no and Manoli Igartua and Hernandez, \{Rosa Maria\} and \{de la Caba\}, Koro and Pedro Guerrero",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jun,

day = "1",

doi = "10.1016/j.carbpol.2020.116159",

language = "English",

volume = "237",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Structure-properties relationship of chitosan/collagen films with potential for biomedical applications

AU - Andonegi, Mireia

AU - Heras, Kevin Las

AU - Santos-Vizcaíno, Edorta

AU - Igartua, Manoli

AU - Hernandez, Rosa Maria

AU - de la Caba, Koro

AU - Guerrero, Pedro

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Chitosan/collagen films were developed and characterized in order to assess the suitability of these films for biomedical applications. Hence, physicochemical, thermal, barrier and mechanical properties were analyzed and related to the film structure, which showed the prevalence of the triple helix of native collagen after the addition of chitosan. Furthermore, collagen fiber diameter changed from 3.9 ± 0.6 μm, for collagen films without chitosan, to 1.8 ± 0.5 μm, for collagen films with low molecular weight chitosan. These results suggested interactions between collagen and chitosan molecules, as observed by Fourier transform infrared (FTIR) analysis. Regarding film barrier properties, chitosan/collagen films showed a water vapor transmission rate around 1174 g m−2 day−1, suitable for biomedical applications such as wound healing. Additionally, biological tests confirmed that the chitosan/collagen films developed are suitable for biomedical applications.

AB - Chitosan/collagen films were developed and characterized in order to assess the suitability of these films for biomedical applications. Hence, physicochemical, thermal, barrier and mechanical properties were analyzed and related to the film structure, which showed the prevalence of the triple helix of native collagen after the addition of chitosan. Furthermore, collagen fiber diameter changed from 3.9 ± 0.6 μm, for collagen films without chitosan, to 1.8 ± 0.5 μm, for collagen films with low molecular weight chitosan. These results suggested interactions between collagen and chitosan molecules, as observed by Fourier transform infrared (FTIR) analysis. Regarding film barrier properties, chitosan/collagen films showed a water vapor transmission rate around 1174 g m−2 day−1, suitable for biomedical applications such as wound healing. Additionally, biological tests confirmed that the chitosan/collagen films developed are suitable for biomedical applications.

KW - Biomaterial

KW - Chitosan

KW - Collagen

KW - Film

KW - Triple helix

UR - https://www.scopus.com/pages/publications/85081652800

U2 - 10.1016/j.carbpol.2020.116159

DO - 10.1016/j.carbpol.2020.116159

M3 - Article

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AN - SCOPUS:85081652800

SN - 0144-8617

VL - 237

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 116159

ER -

Structure-properties relationship of chitosan/collagen films with potential for biomedical applications

Abstract

Keywords

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