TY - GEN
T1 - Tapered optical fiber biosensor for the detection of anti-gliadin antibodies
AU - Corres, J. M.
AU - Bravo, J.
AU - Matias, I. R.
AU - Arregui, F. J.
PY - 2007
Y1 - 2007
N2 - In this paper a new fiber optic sensor for the detection of antibodies to gliadin, in order to aid the diagnosis of celiac disease, is presented. Optical fibers of 200/230 μm (core and cladding diameters respectively) were tapered to a waist diameter in the range of 15-20μm, and then the specific antigen was deposited using the Electrostatic Self-Assembly (ESA) method. Optimal deposition parameters have been selected using an in-situ interferometric characterization technique. The high sensitivity and continuous monitoring of the proposed scheme can reduce importantly the time and serum volume required for celiac disease tests. Performance time is shorter due to the absence of many washing and blocking steps as needed in conventional methods. Additionally, the ESA method allows the construction of nanometric scale recognition surfaces on the fiber optic, which helps to create fast response sensors for real time observation of the binding process.
AB - In this paper a new fiber optic sensor for the detection of antibodies to gliadin, in order to aid the diagnosis of celiac disease, is presented. Optical fibers of 200/230 μm (core and cladding diameters respectively) were tapered to a waist diameter in the range of 15-20μm, and then the specific antigen was deposited using the Electrostatic Self-Assembly (ESA) method. Optimal deposition parameters have been selected using an in-situ interferometric characterization technique. The high sensitivity and continuous monitoring of the proposed scheme can reduce importantly the time and serum volume required for celiac disease tests. Performance time is shorter due to the absence of many washing and blocking steps as needed in conventional methods. Additionally, the ESA method allows the construction of nanometric scale recognition surfaces on the fiber optic, which helps to create fast response sensors for real time observation of the binding process.
UR - https://www.scopus.com/pages/publications/48349098698
U2 - 10.1109/ICSENS.2007.4388472
DO - 10.1109/ICSENS.2007.4388472
M3 - Conference contribution
AN - SCOPUS:48349098698
SN - 1424412617
SN - 9781424412617
T3 - Proceedings of IEEE Sensors
SP - 608
EP - 611
BT - The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
T2 - 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Y2 - 28 October 2007 through 31 October 2007
ER -