The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study

M. Medrano; E. Maiz; Sara Maldonado-Martin; L. Arenaza; B. Rodríguez-Vigil; F.B. Ortega; J.R. Ruiz; E. Larrarte; I. Diez-López; A. Sarasúa-Miranda; I. Tobalina; L. Barrenechea; J. Pérez-Asenjo; S. Kannengiesser; A. Manhães-Savio; O. Echaniz; I. Labayen

doi:10.1016/j.cct.2015.09.017

The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study

M. Medrano, E. Maiz, Sara Maldonado-Martin, L. Arenaza, B. Rodríguez-Vigil, F.B. Ortega, J.R. Ruiz, E. Larrarte, I. Diez-López, A. Sarasúa-Miranda, I. Tobalina, L. Barrenechea, J. Pérez-Asenjo, S. Kannengiesser, A. Manhães-Savio, O. Echaniz, I. Labayen

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Abstract

Background: Non-alcoholic fatty liver disease is the most frequent liver abnormality observed in overweight or obese children and is strongly associated with metabolic syndrome and insulin resistance. Objectives: (i) To evaluate the effect of a 22-week multidisciplinary intervention program on hepatic fat fraction in overweight or obese children and (ii) to examine the effect of the intervention on cardiometabolic risk factors, self-esteem and well-being. Methods: A total of 160 children, 9-11 years, will be recruited by pediatricians and randomly assigned to control (N = 80) or intervention (N = 80) groups. The control group will receive a family-based lifestyle and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week). The duration of training sessions will be 90 min of exercise, including warm-up, moderate to vigorous aerobic activities, and strength exercises. The primary outcome is the change in hepatic fat fraction (magnetic resonance imaging, MRI). Secondary outcomes include cardiometabolic risk factors such as total adiposity (dual Xray absorptiometry), visceral adiposity (MRI), functional peak aerobic capacity (cardiopulmonary exercise testing), blood pressure, muscular fitness, speed-agility, and fasting blood insulin, glucose, C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, lipid profile and psychological measurements (questionnaires). All the measurements will be evaluated at baseline prior to randomization and after the intervention. Discussion: This study will provide insight in the efficacy of a multidisciplinary intervention program including healthy lifestyle education, psycho-education and supervised exercise to reduce hepatic fat and cardiometabolic risk in overweight children

Original language	English
Pages (from-to)	346-355
Number of pages	10
Journal	unknown
Volume	unknown
DOIs	https://doi.org/10.1016/j.cct.2015.09.017
Publication status	Published - 1 Nov 2015

Keywords

Fatty liver
Obesity
Children
Exercise
Metabolic syndrome

Project and Funding Information

Funding Info
Spanish Ministry of Health,_x000D_ Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III PI13/01335, _x000D_ Fondos Estructurales de la Union Europea (FEDER)_x000D_ University of the Basque Country

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cct.2015.09.017

Cite this

Medrano, M., Maiz, E., Maldonado-Martin, S., Arenaza, L., Rodríguez-Vigil, B., Ortega, F. B., Ruiz, J. R., Larrarte, E., Diez-López, I., Sarasúa-Miranda, A., Tobalina, I., Barrenechea, L., Pérez-Asenjo, J., Kannengiesser, S., Manhães-Savio, A., Echaniz, O., & Labayen, I. (2015). The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study. unknown, unknown, 346-355. https://doi.org/10.1016/j.cct.2015.09.017

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title = "The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study",

abstract = "Background: Non-alcoholic fatty liver disease is the most frequent liver abnormality observed in overweight or obese children and is strongly associated with metabolic syndrome and insulin resistance. Objectives: (i) To evaluate the effect of a 22-week multidisciplinary intervention program on hepatic fat fraction in overweight or obese children and (ii) to examine the effect of the intervention on cardiometabolic risk factors, self-esteem and well-being. Methods: A total of 160 children, 9-11 years, will be recruited by pediatricians and randomly assigned to control (N = 80) or intervention (N = 80) groups. The control group will receive a family-based lifestyle and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week). The duration of training sessions will be 90 min of exercise, including warm-up, moderate to vigorous aerobic activities, and strength exercises. The primary outcome is the change in hepatic fat fraction (magnetic resonance imaging, MRI). Secondary outcomes include cardiometabolic risk factors such as total adiposity (dual Xray absorptiometry), visceral adiposity (MRI), functional peak aerobic capacity (cardiopulmonary exercise testing), blood pressure, muscular fitness, speed-agility, and fasting blood insulin, glucose, C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, lipid profile and psychological measurements (questionnaires). All the measurements will be evaluated at baseline prior to randomization and after the intervention. Discussion: This study will provide insight in the efficacy of a multidisciplinary intervention program including healthy lifestyle education, psycho-education and supervised exercise to reduce hepatic fat and cardiometabolic risk in overweight children",

keywords = "Fatty liver, Obesity, Children, Exercise, Metabolic syndrome, Fatty liver, Obesity, Children, Exercise, Metabolic syndrome",

author = "M. Medrano and E. Maiz and Sara Maldonado-Martin and L. Arenaza and B. Rodr{\'i}guez-Vigil and F.B. Ortega and J.R. Ruiz and E. Larrarte and I. Diez-L{\'o}pez and A. Saras{\'u}a-Miranda and I. Tobalina and L. Barrenechea and J. P{\'e}rez-Asenjo and S. Kannengiesser and A. Manh{\~a}es-Savio and O. Echaniz and I. Labayen",

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doi = "10.1016/j.cct.2015.09.017",

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Medrano, M, Maiz, E, Maldonado-Martin, S, Arenaza, L, Rodríguez-Vigil, B, Ortega, FB, Ruiz, JR, Larrarte, E, Diez-López, I, Sarasúa-Miranda, A, Tobalina, I, Barrenechea, L, Pérez-Asenjo, J, Kannengiesser, S, Manhães-Savio, A, Echaniz, O & Labayen, I 2015, 'The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study', unknown, vol. unknown, pp. 346-355. https://doi.org/10.1016/j.cct.2015.09.017

TY - JOUR

T1 - The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study

T2 - Protocol of the EFIGRO study

AU - Medrano, M.

AU - Maiz, E.

AU - Maldonado-Martin, Sara

AU - Arenaza, L.

AU - Rodríguez-Vigil, B.

AU - Ortega, F.B.

AU - Ruiz, J.R.

AU - Larrarte, E.

AU - Diez-López, I.

AU - Sarasúa-Miranda, A.

AU - Tobalina, I.

AU - Barrenechea, L.

AU - Pérez-Asenjo, J.

AU - Kannengiesser, S.

AU - Manhães-Savio, A.

AU - Echaniz, O.

AU - Labayen, I.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Non-alcoholic fatty liver disease is the most frequent liver abnormality observed in overweight or obese children and is strongly associated with metabolic syndrome and insulin resistance. Objectives: (i) To evaluate the effect of a 22-week multidisciplinary intervention program on hepatic fat fraction in overweight or obese children and (ii) to examine the effect of the intervention on cardiometabolic risk factors, self-esteem and well-being. Methods: A total of 160 children, 9-11 years, will be recruited by pediatricians and randomly assigned to control (N = 80) or intervention (N = 80) groups. The control group will receive a family-based lifestyle and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week). The duration of training sessions will be 90 min of exercise, including warm-up, moderate to vigorous aerobic activities, and strength exercises. The primary outcome is the change in hepatic fat fraction (magnetic resonance imaging, MRI). Secondary outcomes include cardiometabolic risk factors such as total adiposity (dual Xray absorptiometry), visceral adiposity (MRI), functional peak aerobic capacity (cardiopulmonary exercise testing), blood pressure, muscular fitness, speed-agility, and fasting blood insulin, glucose, C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, lipid profile and psychological measurements (questionnaires). All the measurements will be evaluated at baseline prior to randomization and after the intervention. Discussion: This study will provide insight in the efficacy of a multidisciplinary intervention program including healthy lifestyle education, psycho-education and supervised exercise to reduce hepatic fat and cardiometabolic risk in overweight children

AB - Background: Non-alcoholic fatty liver disease is the most frequent liver abnormality observed in overweight or obese children and is strongly associated with metabolic syndrome and insulin resistance. Objectives: (i) To evaluate the effect of a 22-week multidisciplinary intervention program on hepatic fat fraction in overweight or obese children and (ii) to examine the effect of the intervention on cardiometabolic risk factors, self-esteem and well-being. Methods: A total of 160 children, 9-11 years, will be recruited by pediatricians and randomly assigned to control (N = 80) or intervention (N = 80) groups. The control group will receive a family-based lifestyle and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week). The duration of training sessions will be 90 min of exercise, including warm-up, moderate to vigorous aerobic activities, and strength exercises. The primary outcome is the change in hepatic fat fraction (magnetic resonance imaging, MRI). Secondary outcomes include cardiometabolic risk factors such as total adiposity (dual Xray absorptiometry), visceral adiposity (MRI), functional peak aerobic capacity (cardiopulmonary exercise testing), blood pressure, muscular fitness, speed-agility, and fasting blood insulin, glucose, C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, lipid profile and psychological measurements (questionnaires). All the measurements will be evaluated at baseline prior to randomization and after the intervention. Discussion: This study will provide insight in the efficacy of a multidisciplinary intervention program including healthy lifestyle education, psycho-education and supervised exercise to reduce hepatic fat and cardiometabolic risk in overweight children

KW - Fatty liver

KW - Obesity

KW - Children

KW - Exercise

KW - Metabolic syndrome

KW - Fatty liver

KW - Obesity

KW - Children

KW - Exercise

KW - Metabolic syndrome

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U2 - 10.1016/j.cct.2015.09.017

DO - 10.1016/j.cct.2015.09.017

M3 - Article

C2 - 26408054

VL - unknown

SP - 346

EP - 355

JO - unknown

JF - unknown

ER -

The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study

Abstract

Keywords

Project and Funding Information

UN SDGs

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