Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels

I. Katime; R. Novoa; E. Díaz De Apodaca; E. Mendizábal; J. Puig

doi:10.1016/S0142-9418(98)00054-3

Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels

I. Katime^*
, R. Novoa
, E. Díaz De Apodaca
, E. Mendizábal
, J. Puig

^*Corresponding author for this work

Universidad de Guadalajara

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 °C, was investigated. It was observed that the liberation mechanism was non-Fickian. Diffusion coefficients according to Ficks law as a function of concentration of N,N′-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported.

Original language	English
Pages (from-to)	559-566
Number of pages	8
Journal	Polymer Testing
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/S0142-9418(98)00054-3
Publication status	Published - Oct 1999
Externally published	Yes

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title = "Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels",

abstract = "Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 °C, was investigated. It was observed that the liberation mechanism was non-Fickian. Diffusion coefficients according to Ficks law as a function of concentration of N,N′-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported.",

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T1 - Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels

AU - Katime, I.

AU - Novoa, R.

AU - Díaz De Apodaca, E.

AU - Mendizábal, E.

AU - Puig, J.

PY - 1999/10

Y1 - 1999/10

N2 - Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 °C, was investigated. It was observed that the liberation mechanism was non-Fickian. Diffusion coefficients according to Ficks law as a function of concentration of N,N′-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported.

AB - Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water but preserve their shape. The dynamic swelling behavior of poly(acrylic acid-co-acrylamide) copolymers, at 37 °C, was investigated. It was observed that the liberation mechanism was non-Fickian. Diffusion coefficients according to Ficks law as a function of concentration of N,N′-methylenebisacrylamide and results on the effects of crosslink density on the release of theophylline are reported.

UR - https://www.scopus.com/pages/publications/0032664364

U2 - 10.1016/S0142-9418(98)00054-3

DO - 10.1016/S0142-9418(98)00054-3

M3 - Article

AN - SCOPUS:0032664364

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VL - 18

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EP - 566

JO - Polymer Testing

JF - Polymer Testing

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ER -

Theophylline release from poly(acrylic acid-co-acrylamide) hydrogels

Abstract

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