TY - JOUR
T1 - Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs
AU - Argarate, Nerea
AU - Olalde, Beatriz
AU - Atorrasagasti, Garbiñe
AU - Valero, Jesus
AU - Carolina Cifuentes, Sandra
AU - Benavente, Rosario
AU - Lieblich, Marcela
AU - Luis González-Carrasco, José
PY - 2014/10/1
Y1 - 2014/10/1
N2 - A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.
AB - A novel bone substitute incorporating biodegradable coatings on poly(d,l-lactide-co-lactide) (PLDL) implant has been developed. The polymer coatings were investigated as carrier of eugenol (EG) and dexamethasone (DM) which are suitable drugs to give antibacterial and anti-inflammatory function to the implant. The dip coating method was employed to coat the PLDL implant with poly(l-lactic acid) (PLLA) polymer. It has been observed that the thickness of the coating increased with the polymer concentration and the repetition of the dipping process showed an additive coating thickness compared to the single dipping. Moreover, it has been proved that a sequential drug release of EG and DM has been reached by incorporating the drugs onto each layer coating.
KW - Biodegradable polymers
KW - Controlled release
KW - Dip coating
KW - Orthopaedic implants
UR - http://www.scopus.com/inward/record.url?scp=84903981054&partnerID=8YFLogxK
U2 - 10.1016/j.matlet.2014.06.070
DO - 10.1016/j.matlet.2014.06.070
M3 - Article
AN - SCOPUS:84903981054
SN - 0167-577X
VL - 132
SP - 193
EP - 195
JO - Materials Letters
JF - Materials Letters
ER -