TY - JOUR
T1 - Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis
T2 - An ENIGMA Analysis
AU - Zavaliangos‐Petropulu, Artemis
AU - Lo, Bethany
AU - Donnelly, Miranda R.
AU - Schweighofer, Nicolas
AU - Lohse, Keith
AU - Jahanshad, Neda
AU - Barisano, Giuseppe
AU - Banaj, Nerisa
AU - Borich, Michael R.
AU - Boyd, Lara A.
AU - Buetefisch, Cathrin M.
AU - Byblow, Winston D.
AU - Cassidy, Jessica M.
AU - Charalambous, Charalambos C.
AU - Conforto, Adriana B.
AU - DiCarlo, Julie A.
AU - Dula, Adrienne N.
AU - Egorova‐Brumley, Natalia
AU - Etherton, Mark R.
AU - Feng, Wuwei
AU - Fercho, Kelene A.
AU - Geranmayeh, Fatemeh
AU - Hanlon, Colleen A.
AU - Hayward, Kathryn S.
AU - Hordacre, Brenton
AU - Kautz, Steven A.
AU - Khlif, Mohamed Salah
AU - Kim, Hosung
AU - Kuceyeski, Amy
AU - Lin, David J.
AU - Liu, Jingchun
AU - Lotze, Martin
AU - MacIntosh, Bradley J.
AU - Margetis, John L.
AU - Mohamed, Feroze B.
AU - Piras, Fabrizio
AU - Ramos‐Murguialday, Ander
AU - Revill, Kate P.
AU - Roberts, Pamela S.
AU - Robertson, Andrew D.
AU - Schambra, Heidi M.
AU - Seo, Na Jin
AU - Shiroishi, Mark S.
AU - Stinear, Cathy M.
AU - Soekadar, Surjo R.
AU - Spalletta, Gianfranco
AU - Taga, Myriam
AU - Tang, Wai Kwong
AU - Thielman, Gregory T.
AU - Vecchio, Daniela
AU - Ward, Nick S.
AU - Westlye, Lars T.
AU - Werden, Emilio
AU - Winstein, Carolee
AU - Wittenberg, George F.
AU - Wolf, Steven L.
AU - Wong, Kristin A.
AU - Yu, Chunshui
AU - Brodtmann, Amy
AU - Cramer, Steven C.
AU - Thompson, Paul M.
AU - Liew, Sook‐Lei
AU - Zavaliangos-Petropulu, Artemis
AU - Egorova-Brumley, Natalia
AU - Ramos-Murguialday, Ander
N1 - S.-L.L. is supported by NIH K01 HD091283; NIH R01 NS115845. A.B. and M.S.K. are supported by National Health and Medical Research Council (NHMRC) GNT1020526, GNT1045617 (A.B.), GNT1094974, and Heart Foundation Future Leader Fellowship 100784 (A.B.). P.M.T. is supported by NIH U54 EB020403. L.A.B. is supported by the Canadian Institutes of Health Research (CIHR). C.M.B. is supported by NIH R21 HD067906. W.D.B. is supported by the Heath Research Council of New Zealand. J.M.C. is supported by NIH R00HD091375. A.B.C. is supported by NIH R01NS076348-01, Hospital Israelita Albert Einstein 2250-14, CNPq/305568/2016-7. A.N.D. is supported by funding provided by the Texas Legislature to the Lone Star Stroke Clinical Trial Network. Its contents are solely the responsibility of the authors and do not necessarily represent the of ficial views of the Government of the United States or the State of Texas. N.E.-B. is supported by Australian Research Council NIH DE180100893. W.F. is sup ported by NIH P20 GM109040. F.G. is supported by Wellcome Trust (093957). B.H. is funded by and NHMRC fellowship (1125054). S.A.K is supported by NIH P20 HD109040. F.B. is supported by Italian Ministry of Health, RC 20, 21. N.S. is supported by NIH R21NS120274. N.J.S. is supported by NIH/National Institute of General Medical Sciences (NIGMS) 2P20GM109040-06, U54-GM104941. S.R.S. is supported by European Research Council (ERC) (NGBMI, 759370). G.S. is supported by Italian Ministry of Health RC 18-19-20-21A. M.T. is sup ported by National Institute of Neurological Disorders and Stroke (NINDS) R01 NS110696. G.T.T. is supported by Temple University sub-award of NIH R24 –NHLBI (Dr Mickey Selzer) Center for Experimental Neurorehabilitation Training. N.J.S. is funded by NIH/National Institute of Child Health and Human Development (NICHD) 1R01HD094731-01A1.
PY - 2022/5/17
Y1 - 2022/5/17
N2 - Background.
Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment.
Methods and Results.
Cross‐sectional T1‐weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta‐Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA‐UE (Fugl‐Meyer Assessment of Upper Extremity). Robust mixed‐effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni‐corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15).
Conclusions.
The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
AB - Background.
Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment.
Methods and Results.
Cross‐sectional T1‐weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta‐Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA‐UE (Fugl‐Meyer Assessment of Upper Extremity). Robust mixed‐effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni‐corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15).
Conclusions.
The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
KW - Sensorimotor impairment
KW - Sensorimotor impairment
KW - Hippocampus
KW - MRI
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85130644416&partnerID=8YFLogxK
U2 - 10.1161/JAHA.121.025109
DO - 10.1161/JAHA.121.025109
M3 - Article
C2 - 35574963
SN - 2047-9980
VL - 11
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 10
M1 - e025109
ER -
