Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

Iñaki Ortego-Isasa; Juan Francisco Ortega-Morán; Héctor Lozano; Thomas Stieglitz; Francisco M. Sánchez-Margallo; Jesús Usón-Gargallo; J. Blas Pagador; Ander Ramos-Murguialday

doi:10.3390/biomedicines12030481

Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

Iñaki Ortego-Isasa^*, Juan Francisco Ortega-Morán, Héctor Lozano, Thomas Stieglitz, Francisco M. Sánchez-Margallo, Jesús Usón-Gargallo, J. Blas Pagador^*, Ander Ramos-Murguialday

^*Autor correspondiente de este trabajo

Medical Technologies

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

Resumen

Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

Idioma original	Inglés
Número de artículo	481
Publicación	Biomedicines
Volumen	12
N.º	3
DOI	https://doi.org/10.3390/biomedicines12030481
Estado	Publicada - mar 2024

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title = "Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review",

abstract = "Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.",

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AU - Ortego-Isasa, Iñaki

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AU - Lozano, Héctor

AU - Stieglitz, Thomas

AU - Sánchez-Margallo, Francisco M.

AU - Usón-Gargallo, Jesús

AU - Pagador, J. Blas

AU - Ramos-Murguialday, Ander

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N2 - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

AB - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

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KW - neural implant

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U2 - 10.3390/biomedicines12030481

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Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review

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