TY - JOUR
T1 - Colonic Electrical Stimulation for Chronic Constipation
T2 - A Perspective Review
AU - Ortego-Isasa, Iñaki
AU - Ortega-Morán, Juan Francisco
AU - Lozano, Héctor
AU - Stieglitz, Thomas
AU - Sánchez-Margallo, Francisco M.
AU - Usón-Gargallo, Jesús
AU - Pagador, J. Blas
AU - Ramos-Murguialday, Ander
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/3
Y1 - 2024/3
N2 - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.
AB - Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.
KW - bioelectronics
KW - colonic electric stimulation (CES)
KW - constipation
KW - neural implant
UR - https://www.scopus.com/pages/publications/85188660365
U2 - 10.3390/biomedicines12030481
DO - 10.3390/biomedicines12030481
M3 - Review article
AN - SCOPUS:85188660365
SN - 2227-9059
VL - 12
JO - Biomedicines
JF - Biomedicines
IS - 3
M1 - 481
ER -