TY - GEN
T1 - Fiber-optics
T2 - 7th European Workshop on Optical Fibre Sensors, EWOFS 2019
AU - Zubiate, Pablo
AU - Santano, Desiree
AU - Urrutia, Aitor
AU - Zamarreño, Carlos R.
AU - Díaz, Silvia
AU - Matias, Ignacio R.
AU - Arregui, Francisco J.
AU - Giannetti, Ambra
AU - Baldini, Francesco
AU - Fernández-Irigoyen, Joaquín
AU - Santamaría, Enrique
AU - Sinibaldi, Alberto
AU - Michelotti, Francesco
AU - Janner, Davide
AU - Guo, Tuan
AU - Del Villar, Ignacio
AU - Chiavaioli, Francesco
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - The combination of fiber-optic-based platforms for biosensing with nanotechnologies is opening up the chance for the development of in situ, portable, lightweight, versatile, reliable and high-performance optical sensing devices. The route consists of the generation of lossy mode resonances (LMRs) by means of the deposition of nm-Thick absorbing metaloxide films on special geometric-modified fibers. This allows measuring precisely and accurately the changes in surface refractive index due to the binding interaction between a biological recognition element and the analyte, with very high sensitivity compared to other optical technology platforms, such as fiber gratings or surface plasmon resonance. The proposed methodology, mixed with the use of specialty fiber structures such as D-shaped fibers, allows improving the light-matter interaction in a strong way. The shift of the LMR has been used to monitor in real-Time the biomolecule interactions thanks to a conventional wavelength-interrogation system and an ad-hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in real samples of human serum. The biosensor regeneration has been also studied by using a solution of sodium dodecyl sulphate (SDS), proving the device reusability. Therefore, this technology possibly represents a paradigm shift in the development of a simple, high-specificity and label-free biosensing platform, which can be applied to speed up diagnostic healthcare processes of different diseases toward an early diagnostic and personalized treatment system.
AB - The combination of fiber-optic-based platforms for biosensing with nanotechnologies is opening up the chance for the development of in situ, portable, lightweight, versatile, reliable and high-performance optical sensing devices. The route consists of the generation of lossy mode resonances (LMRs) by means of the deposition of nm-Thick absorbing metaloxide films on special geometric-modified fibers. This allows measuring precisely and accurately the changes in surface refractive index due to the binding interaction between a biological recognition element and the analyte, with very high sensitivity compared to other optical technology platforms, such as fiber gratings or surface plasmon resonance. The proposed methodology, mixed with the use of specialty fiber structures such as D-shaped fibers, allows improving the light-matter interaction in a strong way. The shift of the LMR has been used to monitor in real-Time the biomolecule interactions thanks to a conventional wavelength-interrogation system and an ad-hoc developed microfluidics. A big leap in performance has been attained by detecting femtomolar concentrations in real samples of human serum. The biosensor regeneration has been also studied by using a solution of sodium dodecyl sulphate (SDS), proving the device reusability. Therefore, this technology possibly represents a paradigm shift in the development of a simple, high-specificity and label-free biosensing platform, which can be applied to speed up diagnostic healthcare processes of different diseases toward an early diagnostic and personalized treatment system.
KW - Absorbing metal-oxide nanomaterial
KW - Femtomolar concentration
KW - Fiber-optic sensing platform
KW - Integrated microfluidics
KW - Lossy mode resonance
UR - https://www.scopus.com/pages/publications/85073326508
U2 - 10.1117/12.2540008
DO - 10.1117/12.2540008
M3 - Conference contribution
AN - SCOPUS:85073326508
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Seventh European Workshop on Optical Fibre Sensors
A2 - Kalli, Kyriacos
A2 - Brambilla, Gilberto
A2 - O'Keeffe, Sinead
PB - SPIE
Y2 - 1 October 2019 through 4 October 2019
ER -