Genotoxic activity of halogenated phenylglycine derivatives

Alicia Boto; Juan A. Gallardo; Rosendo Hernández; Francisco Ledo; Ana Muñoz; José R. Murguía; Mauricio Menacho-Márquez; Aurelio Orjales; Carlos J. Saavedra

doi:10.1016/j.bmcl.2006.08.111

Genotoxic activity of halogenated phenylglycine derivatives

Alicia Boto^*
, Juan A. Gallardo
, Rosendo Hernández
, Francisco Ledo
, Ana Muñoz
, José R. Murguía
, Mauricio Menacho-Márquez
, Aurelio Orjales
, Carlos J. Saavedra

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

12 Citas (Scopus)

Resumen

The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

Idioma original	Inglés
Páginas (desde-hasta)	6073-6077
Número de páginas	5
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	16
N.º	23
DOI	https://doi.org/10.1016/j.bmcl.2006.08.111
Estado	Publicada - 1 dic 2006
Publicado de forma externa	Sí

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title = "Genotoxic activity of halogenated phenylglycine derivatives",

abstract = "The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.",

keywords = "Amino acids, Cancer, Cytotoxic, Genotoxic, Phenylglycine",

author = "Alicia Boto and Gallardo, \{Juan A.\} and Rosendo Hern{\'a}ndez and Francisco Ledo and Ana Mu{\~n}oz and Murgu{\'i}a, \{Jos{\'e} R.\} and Mauricio Menacho-M{\'a}rquez and Aurelio Orjales and Saavedra, \{Carlos J.\}",

year = "2006",

month = dec,

day = "1",

doi = "10.1016/j.bmcl.2006.08.111",

language = "English",

volume = "16",

pages = "6073--6077",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "23",

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TY - JOUR

T1 - Genotoxic activity of halogenated phenylglycine derivatives

AU - Boto, Alicia

AU - Gallardo, Juan A.

AU - Hernández, Rosendo

AU - Ledo, Francisco

AU - Muñoz, Ana

AU - Murguía, José R.

AU - Menacho-Márquez, Mauricio

AU - Orjales, Aurelio

AU - Saavedra, Carlos J.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

AB - The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

KW - Amino acids

KW - Cancer

KW - Cytotoxic

KW - Genotoxic

KW - Phenylglycine

UR - https://www.scopus.com/pages/publications/33751035186

U2 - 10.1016/j.bmcl.2006.08.111

DO - 10.1016/j.bmcl.2006.08.111

M3 - Article

C2 - 16990000

AN - SCOPUS:33751035186

SN - 0960-894X

VL - 16

SP - 6073

EP - 6077

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Genotoxic activity of halogenated phenylglycine derivatives

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