@inproceedings{b825ce2d103946f6ac03e7642b7e8b0f,
title = "Human α-thrombin detection platform using aptamers on a silicon nanowire field-effect transistor",
abstract = "We present a silicon nanowire-based field-effect transistor biosensor with Schottky barriers for highly specific and sensitive human α-thrombin detection. The active sensor area is decorated with thrombin-binding aptamers as receptor molecules. Each sensor chip is integrated into a microfluidic device for flow-through measurements. Instantaneous detection is provided by real-time monitoring of FET transfer curves. With this approach, thrombin concentrations between 200 pM and 200 nM are detected in a label-free, real-time manner, covering a wide dynamic range and enabling to distinguish between healthy and pathological levels. The development of simple, miniaturized devices for blood protein detection is highly interesting for medical diagnostics.",
keywords = "Aptamers, Aptasensors, Field effect transistor, Human α-thrombin, Silicon nanowires",
author = "Lotta R{\"o}mhildt and Felix Z{\"o}rgiebel and Bergoi Ibarlucea and Maryam Vahdatzadeh and Larysa Baraban and Gianaurelio Cuniberti and Sebastian Pregl and Weber, \{Walter M.\} and Thomas Mikolajick and J{\"o}rg Opitz",
note = "Publisher Copyright: {\textcopyright} 2017 IEEE; 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017 ; Conference date: 25-09-2017 Through 27-09-2017",
year = "2017",
month = nov,
day = "13",
doi = "10.1109/PATMOS.2017.8106958",
language = "English",
series = "2017 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1--4",
booktitle = "2017 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017",
address = "United States",
}