Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

J. I. Lombrana; F. Mijangos; F. Varona; M. C. Villaran

Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

J. I. Lombrana, F. Mijangos, F. Varona, M. C. Villaran

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Producción científica: Capítulo del libro/informe/acta de congreso › Capítulo › revisión exhaustiva

Resumen

A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

Idioma original	Inglés
Título de la publicación alojada	Unknown Host Publication Title
Editorial	Amsterdam, The Netherlands, Elsevier Science Publishers
ISBN (versión impresa)	0444893520, 9780444893529
Estado	Publicada - 1991

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abstract = "A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)",

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T1 - Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

AU - Lombrana, J. I.

AU - Mijangos, F.

AU - Varona, F.

AU - Villaran, M. C.

PY - 1991

Y1 - 1991

N2 - A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

AB - A simplified mathematical sublimation model is presented to describe the freeze-drying rate. Freeze-drying was simulated for two pharmaceuticals with very different properties. Different operational profiles were obtained for the heating and pressure evolution. Differences observed in the pressure evolution derived from the behaviour of the dried layer surrounding the frozen nucleus are discussed. (P.M.T.)

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M3 - Chapter

AN - SCOPUS:85041153390

SN - 0444893520

SN - 9780444893529

BT - Unknown Host Publication Title

PB - Amsterdam, The Netherlands, Elsevier Science Publishers

ER -

Near-optimum heating profiles in freeze-drying in accordance to the transport parameters and product nature

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